ArticleIET systems biology2018
Non-normality can facilitate pulsing in biomolecular circuits.
Article in IET systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-normality can underlie pulse dynamics in many engineering contexts. However, its role in pulses generated in biomolecular contexts is generally unclear. Here, the authors address this issue using the mathematical tools of linear algebra and systems theory on simple computational models of biomolecular circuits. They find that non-normality is present in standard models of feedforward loops. They used a generalised framework and pseudospectrum analysis to identify non-normality in larger biomolecular circuit models, finding that it correlates well with pulsing dynamics. Finally, they illustrate how these methods can be used to provide analytical support to numerical screens for pulsing dynamics as well as provide guidelines for design.
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