ArticleGlobal health action2018
Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study.
Article in Global health action, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 7 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies.Communications biology · 2024Pooled it
- Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.Nature communications · 2023Pooled it
- Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.American journal of human genetics · 2023Pooled it
- Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness: An Individual Participant Data Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.Nature communications · 2022Pooled it
- Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.International journal of obesity (2005) · 2021Pooled it
- Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study.BMC medicine · 2021Pooled it
- Genetic associations with alcohol drinking initiation and cessation in sub-Saharan African and African ancestry populations.Research square · 2026Article
- A Stratification Method for Identifying Subgroups at High-Risk for Type 2 Diabetes in sub-Saharan Africa.Nature communications · 2026Article
- Comparison of framingham risk model, atherosclerotic cardiovascular disease risk model, and assign risk model in detecting sub-clinical atherosclerosis among DIMAMO residents, Limpopo province, South Africa.Frontiers in cardiovascular medicine · 2026Article
- Article
- Prevalence and determinants of insulin resistance among middle-aged adults in rural northern Ghana: an Awi-Gen cross-sectional study.BMC public health · 2025Article
- Prevalence of Frailty and Associated Sociodemographic, Biomedical, and Biochemical Factors Amongst Participants Residing in Limpopo Province, South Africa.Geriatrics (Basel, Switzerland) · 2025Article
- Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood.medRxiv : the preprint server for health sciences · 2025Article
- The Impact of Research Results Feedback on the Lived Experiences of Elderly Participants in the DIMAMO Health Demographic Site: A Case of AWI-Gen Participants.International journal of environmental research and public health · 2025Article
- A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population.The journal of allergy and clinical immunology. Global · 2025Article
- Leveraging data science to understand and address multimorbidity in sub-Saharan Africa: the MADIVA protocol.BMJ health & care informatics · 2025Article
- A map of blood regulatory variation in South Africans enables GWAS interpretation.Nature genetics · 2025Article
- Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.Diabetologia · 2025Article
- Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations.Circulation. Genomic and precision medicine · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors.
Funding
Abstract
There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent.
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