ArticleCancer medicine2018
A novel inflammation-based nomogram system to predict survival of patients with hepatocellular carcinoma.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis.Disease markers · 2020Pooled it
- Development and Validation of the Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients With Synovial Sarcoma.Frontiers in endocrinology · 2021Trial
- A preoperative inflammatory score-based nomogram predicts overall survival after curative hepatectomy for hepatocellular carcinoma.Discover oncology · 2025Article
- Association of TIMP-2 Expression with Postoperative Prognosis in Hepatocellular Carcinoma Patients and Development of a Predictive Model.Journal of inflammation research · 2025Article
- Predictive factors associated with anastomotic leakage after resection of rectal cancer: a multicenter study with the Hiroshima Surgical study group of Clinical Oncology.Langenbeck's archives of surgery · 2023Article
- Review
- Development and Validation of a Nomogram to Predict Cancer-Specific Survival for Middle-Aged Patients With Early-Stage Hepatocellular Carcinoma.Frontiers in public health · 2022Article
- Prognostic nomogram for the severity of acute organophosphate insecticide self-poisoning: a retrospective observational cohort study.BMJ open · 2021Observational
- Novel Nomograms-Based Prediction Models for Patients with Primary Undifferentiated Pleomorphic Sarcomas Resections.Cancers · 2021Article
- Prognostic value and association of sarcopenic obesity and systemic inflammatory indexes in patients with hepatocellular carcinoma following hepatectomy and the establishment of novel predictive nomograms.Journal of gastrointestinal oncology · 2021Article
- A practical nomogram and risk stratification system predicting the cancer-specific survival for patients with early hepatocellular carcinoma.Cancer medicine · 2021Article
- Preoperative C-Reactive Protein/Albumin Ratio is a Prognostic Indicator for Survival in Surgically Treated Gastrointestinal Stromal Tumors: A Retrospective Cohort Study.Cancer management and research · 2021Article
- Novel inflammation-based prognostic nomograms for individualized prediction in hepatocellular carcinoma after radical resection.Annals of translational medicine · 2020Article
- Tescalcin is an unfavorable prognosis factor that regulats cell proliferation and survival in hepatocellular carcinoma patients.Cancer communications (London, England) · 2020Article
- Hepatocellular Carcinoma Within the Milan Criteria: A Novel Inflammation-Based Nomogram System to Assess the Outcomes of Ablation.Frontiers in oncology · 2020Article
- Nomogram Based on Systemic Immune Inflammation Index and Prognostic Nutrition Index Predicts Recurrence of Hepatocellular Carcinoma After Surgery.Frontiers in oncology · 2020Article
- Verification of inflammation-based prognostic marker as a prognostic indicator in hepatocellular carcinoma.Annals of gastroenterological surgery · 2019Article
- Novel nomograms individually predict the survival of patients with soft tissue sarcomas after surgery.Cancer management and research · 2019Article
- A novel inflammation-based nomogram system to predict survival of patients with hepatocellular carcinoma.Cancer medicine · 2018Article
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11 authors.
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Abstract
BACKGROUND AND
aimThe existed staging systems were limited in the accuracy of prediction for overall survival (OS) of hepatocellular carcinoma (HCC) patients. The aim of this study is to establish a novel inflammation-based prognostic system with nomogram for HCC patients.
methodsA prospective cohort of patients was recruited and assigned to the training cohort (n = 659) and validation cohort (n = 320) randomly. Different inflammation-based score systems were evaluated to select the best one predicting overall survival (OS). The inflammation-based score system with the highest predicting value and the parameters best reflecting tumor burden identified by multivariate analysis were selected to construct a novel predicting nomogram system. The predictive accuracy and discriminative ability of the nomogram were evaluated by concordance index (C-index) and calibration curve and compared with conventional staging systems.
resultsWith a highest C-index and areas under the receiver operating characteristic curve (AUC), C-reactive protein/albumin ratio (CAR) was selected to construct the novel system, along with tumor number, tumor size, macrovascular invasion and extra-hepatic metastases. The C-index of the nomogram was 0.813 (95% CI, 0.789-0.837) in the training cohort and 0.794 (95% CI, 0.756-0.832) in the validation cohort. The calibration curve for predicting probability of survival showed that the nomogram had a high consistency with follow-up data. The C-index of the novel system was higher than other conventional staging systems (P < 0.001).
conclusionsThe novel inflammation-based nomogram, developed from prospectively collected data in the present study, predicted the OS of HCC patients.
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