ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2018
The ipRGC-driven pupil response with light exposure and refractive error in children.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype.Sleep · 2026Article
- The role of circadian rhythms in the pathogenesis of myopia.Frontiers in physiology · 2026Review
- Radiometric and safety assessment of a 'low-level red-light' myopia control device.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Chromatic cues for the sign of defocus in the peripheral retina.Biomedical optics express · 2024Article
- Differences in the pupillary responses to evening light between children and adolescents.Journal of physiological anthropology · 2024Article
- Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia.Investigative ophthalmology & visual science · 2024Article
- The association between pupillary responses and axial length in children differs as a function of season.Scientific reports · 2024Article
- Effects of Insufficient Sleep on Myopia in Children: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2024Review
- Differences in the Pupillary Responses to Evening Light between Children and Adolescents.bioRxiv : the preprint server for biology · 2023Article
- Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.Journal of physiological anthropology · 2023Review
- Using Light Meters to Investigate the Light-Myopia Association - A Literature Review of Devices and Research Methods.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Intrinsically photosensitive retinal ganglion cell-driven pupil responses in patients with traumatic brain injury.Vision research · 2021Article
- Ambient Light Regulates Retinal Dopamine Signaling and Myopia Susceptibility.Investigative ophthalmology & visual science · 2021Article
- Long-Term Narrowband Lighting Influences Activity but Not Intrinsically Photosensitive Retinal Ganglion Cell-Driven Pupil Responses.Frontiers in physiology · 2021Article
- Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia.Scientific reports · 2020Article
- The Effect of Refractive Error on Melanopsin-Driven Pupillary Responses.Investigative ophthalmology & visual science · 2020Article
- Effect of Electrical Stimulation of Cervical Sympathetic Ganglia on Intraocular Pressure Regulation According to Different Circadian Rhythms in Rats.Investigative ophthalmology & visual science · 2020Article
- Effects of Narrowband Light on Choroidal Thickness and the Pupil.Investigative ophthalmology & visual science · 2020Article
- Effects of Mydriatics on Rod/Cone- and Melanopsin-driven Pupil Responses.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
- The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors.Journal of optometryArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeThe intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, control pupil size and entrain circadian rhythm. There is speculation that ipRGCs may be involved in the protective effects of light exposure in myopia. Here, the ipRGC-driven pupil response was evaluated in children and examined with light exposure and refractive error.
methodsChildren ages 5-15 years participated. Subjects wore an actigraph device prior to the lab visit for objective measures of light exposure and sleep. For pupillometry, the left eye was dilated and presented with stimuli, and the consensual pupil response was measured in the right eye. Pupil measurements were preceded by 5 min dark adaptation. In Experiment 1 (n = 14), 1 s long wavelength light ('red,' 651 nm, 167 cd m
resultsFor Experiment 1, PIPR metrics demonstrated a graded response to increasing intensity blue stimuli, with a mean functional melanopsin threshold of 6.2 ± 4.5 cd m
conclusionsThe ipRGC-driven pupil responses in children were robust and similar to responses previously measured in an adult population. The 6 s PIPR and early AUC to high intensity blue stimuli were associated with previous light exposure. There were no associations between the ipRGC-driven pupil response and refractive status in this cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.