Evidence map›Paper›PMID 30259418›Full record

ReviewNeurotoxicity research2019

Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.

Evan A Bordt, Caroline J Smith, Tyler G Demarest, Staci D Bilbo, Marcy A Kingsbury

Open access · greenAbstract readReview
In one paragraph

Review in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025
    Review
  4. Review
  5. Review
  6. Oxytocin, the Love Hormone, in Stem Cell Differentiation.Current issues in molecular biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Close encounters with oxytocin.Comprehensive psychoneuroendocrinology · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  19. Oxytocin and microglia in the development of social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  20. Oxytocin and love: Myths, metaphors and mysteries.Comprehensive psychoneuroendocrinology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Evan A BordtDepartment of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, 02129, USA. ebordt@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0617-2789
Caroline J SmithDepartment of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, 02129, USA.
Tyler G DemarestLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Staci D BilboDepartment of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, 02129, USA.
Marcy A KingsburyDepartment of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, 02129, USA.
Harvard University · USNational Institutes of Health · US

Funding

Environmental Toxins and Microglia-Synapse Interactions in AutismR01ES025549 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D, DZIRASA, KAFUI · 2016 to 2020
$2.1M
Sex Differences in Developing Microglia: Implications for Synaptic PruningR01MH101183 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D · 2013 to 2017
$2.0M
Social and Motivational Properties of Vasoactive Intestinal Polypeptide CircuitsR01MH092331 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI KINGSBURY, MARCY A · 2011 to 2015
$1.9M
Neural-Glial Interactions and Opioid Abuse: Modulation by Early-Life ExperienceR01DA034185 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D · 2013 to 2017
$1.8M
Sex-Biased Mitochondrial Alterations Underlying Male Susceptibility to Neurodevelopmental DisordersF32MH116604 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BORDT, EVAN ANDREW · 2018 to 2021
$217k
NIDA NIH HHS R01 DA034185NIEHS NIH HHS ES025549NIEHS NIH HHS R01 ES025549NIMH NIH HHS F32 MH116604NIMH NIH HHS MH092331NIMH NIH HHS MH101183NIMH NIH HHS R01 MH092331NIMH NIH HHS R01 MH101183
6 · The paper itself

Abstract

Neuroendocrine and immune signaling pathways are activated following insults such as stress, injury, and infection, in a systemic response aimed at restoring homeostasis. Mitochondrial metabolism and function have been implicated in the control of immune responses. Commonly studied along with mitochondrial function, reactive oxygen species (ROS) are closely linked to cellular inflammatory responses. It is also accepted that cells experiencing mitochondrial or endoplasmic reticulum (ER) stress induce response pathways in order to cope with protein-folding dysregulation, in homeostatic responses referred to as the unfolded protein responses (UPRs). Recent reports indicate that the UPRs may play an important role in immune responses. Notably, the homeostasis-regulating hormones oxytocin (OXT) and vasopressin (AVP) are also associated with the regulation of inflammatory responses and immune function. Intriguingly, OXT and AVP have been linked with ER unfolded protein responses (UPR

Indexed as

Protein FoldingAnimalsHumansImmunity, CellularInflammationMacrophagesMitochondriaOxytocinReactive Oxygen SpeciesVasopressinsOxytocinReactive Oxygen SpeciesVasopressinsGlutathioneMicrogliaNADPH oxidaseNF-κBUnfolded protein response

Identifiers

PMID30259418
PMCPMC7416501
OpenAlexW2892639773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.