Evidence map›Paper›PMID 30259344›Full record

ArticleIntensive care medicine experimental2018

Tight junction structure, function, and assessment in the critically ill: a systematic review.

David Vermette, Pamela Hu, Michael F Canarie, Melissa Funaro, Janis Glover, Richard W Pierce

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 130 citations in OpenAlex.

  1. Review
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  20. Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC - What is Coming Next?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David VermetteDepartment of Pediatrics, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA.
Pamela HuDepartment of Pediatrics, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA.
Michael F CanarieDepartment of Pediatrics, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA.
Melissa FunaroCushing/Whitney Medical Library, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA.
Janis GloverCushing/Whitney Medical Library, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA.
Richard W PierceDepartment of Pediatrics, Yale University, 333 Cedar Street, PO Box 208064, New Haven, CT, 06520, USA. Richard.Pierce@yale.edu.
Yale University · USWhitney Museum of American Art · US

Funding

YALE PEDIATRIC BASIC SCIENCE TRAINING PROGRAMT32HD068201 · NICHD · YALE UNIVERSITY · PI EGAN, MARIE E · 2011 to 2015
$1.3M
Mechanisms of Endothelial Cell Dysfunction in Critically Ill ChildrenK08HL136898 · NHLBI · YALE UNIVERSITY · PI PIERCE, RICHARD W · 2019 to 2023
$780k
NICHD NIH HHS T32 HD068201
6 · The paper itself

Abstract

backgroundEpithelial and endothelial barrier integrity, essential for homeostasis, is maintained by cellular boarder structures known as tight junctions (TJs). In critical illness, TJs may become disrupted, resulting in barrier dysfunction manifesting as capillary leak, pulmonary edema, gut bacterial translocation, and multiple organ failure. We aim to provide a clinically focused overview of TJ structure and function and systematically review and analyze all studies assessing markers of endothelial and epithelial TJ breakdown correlated with clinical outcomes in critically ill humans.

methodsWe systematically searched MEDLINE, EMBASE, and PubMed. Additional articles were identified by targeted searches. We included studies that looked at the relationship between biomarkers of endothelial or epithelial TJ structure or function and critical illness. Results were qualitatively analyzed due to sample size and heterogeneity.

resultsA total of 5297 abstracts met search criteria, of which 150 articles met requirements for full text review. Of these, 30 studies met inclusion criteria. Fifteen of the 30 reports investigated proteins of endothelial tight junctions and 15 investigated epithelial TJ markers, exclusively in the gastrointestinal epithelium. No studies investigated TJ-derived proteins in primary cardiac or pulmonary pathology.

conclusionsTJ integrity is essential for homeostasis. We identified multiple studies that indicate TJs are disrupted by critical illness. These studies highlight the significance of barrier disruption across many critical disease states and correlate TJ-associated markers to clinically relevant outcomes. Further study on the role of multiple tissue-specific claudins, particularly in the setting of respiratory or cardiac failure, may lead to diagnostic and therapeutic advances. SYSTEMATIC REVIEW REGISTRATION: This systematic review is registered in the PROSPERO database: CRD42017074546 .

Indexed as

Capillary leakCellular permeabilityCritical careEndothelial cellsEpithelial cellsTight junctions

Identifiers

PMID30259344
PMCPMC6158145
OpenAlexW2892782936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.