Evidence map›Paper›PMID 30259334›Full record

ArticleCell biochemistry and biophysics2019

Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies.

Balaraman Kalyanaraman, Gang Cheng, Jacek Zielonka, Brian Bennett

Abstract read
In one paragraph

Article in Cell biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders.Frontiers in cell and developmental biology · 2021
    Review
  6. Article
  7. Article
  8. OXPHOS-targeting drugs in oncology: new perspectives.Expert opinion on therapeutic targets
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Balaraman KalyanaramanDepartment of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. balarama@mcw.edu.ORCID http://orcid.org/0000-0002-9180-8296
Gang ChengDepartment of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Jacek ZielonkaDepartment of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Brian BennettDepartment of Physics, Marquette University, 540 N. 15th St., Milwaukee, WI, 53233, USA. brian.bennett@marquette.edu.
Medical College of Wisconsin · USMarquette University · US

Funding

Chemoprevention of Lung Cancer with Mitochondria-Targeted HonokiolR01CA208648 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KALYANARAMAN, BALARAMAN, YOU, MING · 2017 to 2021
$3.1M
Targeting pancreatic cancer energy metabolism, tumor growth, and metastasisU01CA178960 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MICHAEL B, KALYANARAMAN, BALARAMAN · 2014 to 2018
$2.6M
National Cancer Institute R01 CA208648National Cancer Institute U01 CA178960National Science Foundation CHE-1532168NCI NIH HHS R01 CA208648NCI NIH HHS U01 CA178960
6 · The paper itself

Abstract

Oxidants formed from oxidative and nitrative metabolism include reactive oxygen species (ROS) such as superoxide, hydrogen peroxide/lipid hydroperoxides and reactive nitrogen species (RNS) (e.g., peroxynitrite [ONOO

Indexed as

Electron Spin Resonance SpectroscopyAnimalsAntineoplastic AgentsBiomarkers, TumorDrug Resistance, NeoplasmHumansImmunotherapyMitochondriaMitochondrial ProteinsNeoplasmsOxidative PhosphorylationReactive Nitrogen SpeciesReactive Oxygen SpeciesTemperatureAntineoplastic AgentsBiomarkers, TumorMitochondrial ProteinsReactive Nitrogen SpeciesReactive Oxygen SpeciesElectron paramagnetic resonanceMitochondrial targetingOxidative phosphorylationReactive oxygen species

Identifiers

PMID30259334
PMCPMC6430651
OpenAlexW2893093811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.