Evidence map›Paper›PMID 30259091›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

Clinical translation of [

S R Dubash, S Merchant, K Heinzmann, F Mauri, I Lavdas, M Inglese, K Kozlowski, N Rama, N Masrour, J F Steel and 7 more

Abstract readClinical Trial, Phase I
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A first-in-human study of [European journal of nuclear medicine and molecular imaging · 2022
    Trial
  3. Augmentation of [EJNMMI research · 2025
    Article
  4. First-in-human study of a novel cell death tracer [EJNMMI radiopharmacy and chemistry · 2023
    Article
  5. Article
  6. Review
  7. Radionuclide imaging of apoptosis for clinical application.European journal of nuclear medicine and molecular imaging · 2022
    Review
  8. Article
  9. Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Article
  12. Interest and Limits of [Frontiers in oncology · 2021
    Review
  13. EJNMMI research · 2020
    Article
  14. Article
  15. Article
  16. Development of [Cancers · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

S R DubashDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.ORCID http://orcid.org/0000-0003-3407-5214
S MerchantDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
K HeinzmannDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
F MauriDepartment of Radiology, Imperial College Healthcare NHS Trust, London, UK.
I LavdasDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
M IngleseDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
K KozlowskiDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
N RamaDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
N MasrourDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
J F SteelDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
A ThorntonDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.
A K LimDepartment of Radiology, Imperial College Healthcare NHS Trust, London, UK.
C LewanskiDepartment of Oncology, Imperial College Healthcare NHS Trust, London, UK.
S CleatorDepartment of Oncology, Imperial College Healthcare NHS Trust, London, UK.
R C CoombesDepartment of Oncology, Imperial College Healthcare NHS Trust, London, UK.
Laura KennyDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK. l.kenny@imperial.ac.uk.
Eric O AboagyeDepartment of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK. eric.aboagye@imperial.ac.uk.

Funding

Cancer Research UK 16584Cancer Research UK 18784Cancer Research UK C2536/A10337Medical Research Council A652-5PY80Medical Research Council MC_U120081322Medical Research Council MR/N020782/1
6 · The paper itself

Abstract

backgroundEffective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [

resultsBreast tumour SUV

conclusionThis study highlights the potential use of [

Indexed as

AzidesIndolesPositron-Emission TomographyAdultAgedBreast NeoplasmsCaspase 3Caspase 7Enzyme ActivationFemaleGene Expression Regulation, NeoplasticHumansImage Processing, Computer-AssistedLung NeoplasmsMaleMiddle Aged(18)F-ICMT11AzidesCASP3 protein, humanCaspase 3Caspase 7Indoles[18F]ICMT-11ApoptosisCaspase-3Isatin sulfonamidePositron emission tomography

Identifiers

PMID30259091
PMCPMC6208806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.