ArticlePsychopharmacology2019
Prefrontal circuits signaling active avoidance retrieval and extinction.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation.eLife · 2026Article
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus.Behavioural brain research · 2025Article
- Persistent Threat Avoidance Following Negative Reinforcement Is Not Associated with Elevated State Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review.Cureus · 2025Review
- Social context modulates active avoidance: Contributions of the anterior cingulate cortex in male and female rats.Neurobiology of stress · 2025Article
- Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.PloS one · 2025Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Active avoidance recruits the anterior cingulate cortex regardless of social context in male and female rats.Research square · 2024Article
- A history of avoidance does not impact extinction learning in male rats.NPJ science of learning · 2024Article
- Stressed rats fail to exhibit avoidance reactions to innately aversive social calls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Measuring maladaptive avoidance: from animal models to clinical anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?Neuroscience and biobehavioral reviews · 2021Review
- BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING.Physiological reviews · 2021Review
- Neural Computations of Threat.Trends in cognitive sciences · 2021Review
- Characterizing Different Strategies for Resolving Approach-Avoidance Conflict.Frontiers in neuroscience · 2021Article
- The neurobiological basis of sex differences in learned fear and its inhibition.The European journal of neuroscience · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveNeurons in PL and IL project densely to two areas implicated in active avoidance: the basolateral amygdala (BLA) and the ventral striatum (VS). We therefore combined c-Fos immunohistochemistry with retrograde tracers to characterize signaling in platform-mediated active avoidance.
methodsMale rats were infused with retrograde tracers (CTB, FB) into basolateral amygdala and ventral striatum and conditioned to avoid tone-signaled footshocks by stepping onto a nearby platform. In a subsequent test session, rats received either 2 unreinforced tones (avoidance retrieval) or 15 unreinforced tones (avoidance extinction) followed by analysis of c-Fos combined with fluorescent imaging of retrograde tracers.
resultsRetrieval of avoidance did not activate IL neurons, but did activate PL neurons projecting to BLA, and to a lesser extent VS. Extinction of avoidance activated IL neurons projecting to both BLA and VS, as well as PL neurons projecting to VS.
conclusionsOur observation that avoidance retrieval is signaled by PL projections to BLA suggests that PL may modulate VS indirectly via BLA, and agrees with other findings implicating BLA in active avoidance. Less expected was the signaling of extinction via PL inputs to VS, which may converge with IL inputs to VS to inhibit expression of avoidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.