Evidence map›Paper›PMID 30258975›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2018

Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial.

Kyrana Tsapkini, Kimberly T Webster, Bronte N Ficek, John E Desmond, Chiadi U Onyike, Brenda Rapp, Constantine E Frangakis, Argye E Hillis

4 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 73 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02606422 nacompletednot on this map

Effects of Transcranial Direct Current Stimulation (tDCS) in Spoken and Written Production in Primary Progressive Aphasia (PPA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2013 to 2023Enrolled61ConditionsPrimary Progressive Aphasia, MCI, FTDArmsActive HD-tDCS plus Speech-Language Therapy, Sham plus Speech-Language Therapy
NCT03887481 narecruitingnot on this mapstarted 2022, after this paper: background citation

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Aphasic AD (Logopenic Variant PPA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2027Enrolled60ConditionsLogopenic Progressive Aphasia, Primary Progressive AphasiaArmsHigh-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment
NCT04122001 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Transcranial Direct Current Stimulation in Typical and Atypical Alzheimer's Disease

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2026Enrolled90ConditionsAlzheimer Disease, Early Onset, Atypical Alzheimer's Disease, Logopenic Progressive AphasiaArmsActive, in-person HD-tDCS or active remote tDCS, Sham, Word List Learning Intervention (WordLLI)
NCT05386394 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2028Enrolled180ConditionsPrimary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive AphasiaArmsActive tDCS + Language Therapy, Sham tDCS + Language Therapy
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyrana TsapkiniDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Kimberly T WebsterDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Bronte N FicekDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
John E DesmondDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD, USA.
Brenda RappDepartment of Cognitive Science, Johns Hopkins University, Baltimore, MD, USA.
Constantine E FrangakisDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HICKOK, GREGORY · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
NIA NIH HHS P50 AG005146NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC011317NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

introductionTranscranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown.

methodsThirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment.

resultstDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. DISCUSSION: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.

Indexed as

Alzheimer's diseaseDementiaFrontotemporal dementiaLanguagelvPPANamingnfvPPAPrimary progressive aphasiaSpellingsvPPATreatment

Identifiers

PMID30258975
PMCPMC6153381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.