Evidence map›Paper›PMID 30258904›Full record

ReviewGenes & diseases2017

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism.

Xiu Lv, Jincheng Li, Chuhong Zhang, Tian Hu, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiu LvThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Jincheng LiMedical School, Shaoyang University, Shaoyang, Hunan 422000, China.
Chuhong ZhangThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Tian HuThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Sai LiThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Sha HeThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Hanxing YanThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Yixi TanThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Mingsheng LeiDepartment of Respiratory and Critical Care Medicine, Zhangjiajie City Hospital, Zhangjiajie, Hunan 427000, China.
Meiling WenThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
Jianhong ZuoThe Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.

Indexed as

AngiogenesisHIFHypoxiaMetabolismVHL

Identifiers

PMID30258904
PMCPMC6136595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.