Evidence map›Paper›PMID 30258692›Full record

ArticleBiomedical optics express2018

Biomimetic 3D-printed neurovascular phantoms for near-infrared fluorescence imaging.

Yi Liu, Pejhman Ghassemi, Andrew Depkon, Maria Ida Iacono, Jonathan Lin, Gonzalo Mendoza, Jianting Wang, Qinggong Tang, Yu Chen, T Joshua Pfefer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi LiuDepartment of Bioengineering, University of Maryland, Silver Spring, MD, USA.
Pejhman GhassemiCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Andrew DepkonCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Maria Ida IaconoCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Jonathan LinCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Gonzalo MendozaCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Jianting WangCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Qinggong TangDepartment of Bioengineering, University of Maryland, Silver Spring, MD, USA.
Yu ChenDepartment of Bioengineering, University of Maryland, Silver Spring, MD, USA.
T Joshua PfeferCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging three-dimensional (3D) printing technology enables the fabrication of optically realistic and morphologically complex tissue-simulating phantoms for the development and evaluation of novel optical imaging products. In this study, we assess the potential to print image-defined neurovascular phantoms with patent channels for contrast-enhanced near-infrared fluorescence (NIRF) imaging. An anatomical map defined from clinical magnetic resonance imaging (MRI) was segmented and processed into files suitable for printing a forebrain vessel network in rectangular and curved-surface biomimetic phantoms. Methods for effectively cleaning samples with complex vasculature were determined. A final set of phantoms were imaged with a custom NIRF system at 785 nm excitation using two NIRF contrast agents. In addition to demonstrating the strong potential of 3D printing for creating highly realistic, patient-specific biophotonic phantoms, our work provides insight into optimal methods for accomplishing this goal and elucidates current limitations of this approach.

Indexed as

(170.6280) Spectroscopy, fluorescence and luminescence(180.1655) Coherence tomography

Identifiers

PMID30258692
PMCPMC6154206

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.