ArticleBiomedical optics express2018
Dual-wavelength oblique back-illumination microscopy for the non-invasive imaging and quantification of blood in collection and storage bags.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 43 citations in OpenAlex.
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- Real-time semantic segmentation and anomaly detection of functional images for cell therapy manufacturing.Cytotherapy · 2023Article
- Label-Free Functional Analysis of Root-Associated Microbes with Dynamic Quantitative Oblique Back-illumination Microscopy.Research square · 2023Article
- Analysis of structural effects of sickle cell disease on brain vasculature of mice using three-dimensional quantitative phase imaging.Journal of biomedical optics · 2023Article
- White blood cell classification via a discriminative region detection assisted feature aggregation network.Biomedical optics express · 2022Article
- Functional imaging with dynamic quantitative oblique back-illumination microscopy.Journal of biomedical optics · 2022Article
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- High-speed multifocus phase imaging in thick tissue.Biomedical optics express · 2021Article
- Towards in-vivo label-free detection of brain tumor margins with epi-illumination tomographic quantitative phase imaging.Biomedical optics express · 2021Article
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- Label-free microendoscopy using a micro-needle imaging probe forBiomedical optics express · 2020Article
- Imaging human blood cells in vivo with oblique back-illumination capillaroscopy.Biomedical optics express · 2020Article
- Inverse scattering for reflection intensity phase microscopy.Biomedical optics express · 2020Article
- Epi-mode tomographic quantitative phase imaging in thick scattering samples.Biomedical optics express · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is currently no low-cost method to quantitatively assess the contents of a blood bag without breaching the bag and potentially damaging the sample. Towards this end, we adapt oblique back-illumination microscopy (OBM) to rapidly, inexpensively, and non-invasively screen blood bags for red blood cell (RBC) morphology and white blood cell (WBC) count. OBM has been recently introduced as a tomographic technique that produces high-resolution wide-field images based on phase-gradient and transmission. Here we modify this technique to include illumination at dual wavelengths to facilitate spectral analysis for cell classification. Further, we apply a modified 2D Hilbert transform to recover the phase information from the phase-gradient images for facile cell segmentation. Blood cells are classified as WBCs and RBCs, and counted based on shape, absorption spectrum, and phase profile using an automated algorithm. This work has important implications for the non-invasive assessment of (1) cell viability in storage bags for transfusion applications and (2) suitability of a cord blood collection bag for stem cell therapy applications.
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