ArticleBone & joint research2018
Standardizing compression testing for measuring the stiffness of human bone.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quality assessment tools used in systematic reviews of in vitro studies: A systematic review.BMC medical research methodology · 2021Pooled it
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- Design and validation of a perfusion bioreactor for long-term human bone explant culture.JBMR plus · 2026Article
- Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Ancient Principles, Modern Impact: Increased Femoral Offset Demonstrates Decreased Load to Failure in Total Hip Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Approach to Standardized Material Characterization of the Human Lumbopelvic System: Testing and Evaluation.Bioengineering (Basel, Switzerland) · 2025Article
- Analysis of Biomechanical Characteristics of Bone Tissues Using a Bayesian Neural Network: A Narrative Review.Journal of functional biomaterials · 2025Review
- Surgical mechanical properties of perfused decellularized massive bone allografts: An comparative in vivo test.PloS one · 2025Article
- A Brief Introductory Guide to Nanoindentation for Comparative and Evolutionary Biologists, with a Case Study of Bone Material Property Diversity across Artiodactyl Skulls.Integrative organismal biology (Oxford, England) · 2025Article
- Investigating mechanical properties for developing a human infant cranial bone surrogate in pediatric craniofacial surgery.Heliyon · 2024Article
- Ex Vivo Biomechanical Bone Testing of Pig Femur as an Experimental Model.Bioengineering (Basel, Switzerland) · 2024Article
- A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint.Annals of biomedical engineering · 2024Article
- Strain-mode-specific mechanical testing and the interpretation of bone adaptation in the deer calcaneus.Journal of anatomy · 2024Article
- Characterization of mechanical stiffness using additive manufacturing and finite element analysis: potential tool for bone health assessment.3D printing in medicine · 2023Article
- Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation.PloS one · 2023Article
- Article
- Selected mechanical properties of human cancellous bone subjected to different treatments: short-term immersion in physiological saline and acetone treatment with subsequent immersion in physiological saline.Journal of orthopaedic surgery and research · 2022Article
- Characterizing the Mechanical Behavior of Bone and Bone Surrogates in Compression Using pQCT.Materials (Basel, Switzerland) · 2022Article
- Finite element analysis of trabecular bone microstructure using CT imaging and continuum mechanical modeling.Medical physics · 2022Article
- Patella Strength Characteristics in Cemented vs Press-fit Implants: A Biomechanical Analysis of Initial Stability.Arthroplasty today · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe ability to determine human bone stiffness is of clinical relevance in many fields, including bone quality assessment and orthopaedic prosthesis design. Stiffness can be measured using compression testing, an experimental technique commonly used to test bone specimens
methodsA keyword search of all English language articles up until December 2017 of compression testing of bone was undertaken in Medline, Embase, PubMed, and Scopus databases. Studies using bulk tissue, animal tissue, whole bone, or testing techniques other than compression testing were excluded.
resultsA total of 4712 abstracts were retrieved, with 177 papers included in the analysis; 20 studies directly analyzed the compression testing technique to improve the accuracy of testing. Several influencing factors should be considered when testing bone samples in compression. These include the method of data analysis, specimen storage, specimen preparation, testing configuration, and loading protocol.
conclusionCompression testing is a widely used technique for measuring the stiffness of bone but there is a great deal of inter-study variation in experimental techniques across the literature. Based on best evidence from the literature, suggestions for bone compression testing are made in this review, although further studies are needed to establish standardized bone testing techniques in order to increase the comparability and reliability of bone stiffness studies.
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Registered trials
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