ReviewAnnals of general psychiatry2018
Psychotic (delusional) depression and completed suicide: a systematic review and meta-analysis.
Review in Annals of general psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Prediction of remission of pharmacologically treated psychotic depression: A machine learning approach.Journal of affective disorders · 2025Trial
- Effect of olanzapine exposure on relapse and brain structure in patients with major depressive disorder with psychotic features.Molecular psychiatry · 2024Trial
- Trial
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prevalence and related factors of comorbid suicide attempts and psychotic symptoms in first-episode drug-naïve patients with major depressive disorder.BMC psychiatry · 2025Article
- Clinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study.The Journal of clinical psychiatry · 2025Article
- Service user perspectives and experiences of their diagnosis of psychotic major depression: A qualitative study.PloS one · 2025Article
- Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review.Psychology research and behavior management · 2025Review
- Differences of regional homogeneity and cognitive function between psychotic depression and drug-naïve schizophrenia.BMC psychiatry · 2024Article
- Prevalence and risk factors of suicide attempts in young, first-episode and drug-naïve Chinese Han outpatients with psychotic major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study.BMC psychiatry · 2024Article
- The Arabic Questionnaire for Psychotic Experiences in patients with psychotic disorders: a clinical validation.BMC psychiatry · 2023Article
- Clinical Characteristics, Metabolic Parameters, and Risk Factors for Suicide Attempts Vary with Untreated Major Depressive Disorder Duration.Depression and anxiety · 2023Article
- Mortality in psychotic depression: 18-year follow-up study.The British journal of psychiatry : the journal of mental science · 2023Article
- Relationship among psychotic features, benzodiazepine receptor agonists, and rehospitalization in patients with electroconvulsive therapy-responsive major depressive disorder: A retrospective 2-year observational study.Neuropsychopharmacology reports · 2022Observational
- Clinical Approaches to Late-Onset Psychosis.Journal of personalized medicine · 2022Review
- Cross-continental collaboration for understanding postpartum major depression with psychotic features.Frontiers in global women's health · 2022Article
- Suicidal ideation during COVID-19 lockdown in Greece: Prevalence in the community, risk and protective factors.Psychiatry research · 2021Article
- Recent Updates on Electro-Convulsive Therapy in Patients with Depression.Psychiatry investigation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt remains unclear whether psychotic features increase the risk of completed suicides in unipolar depression. The present systematic review coupled with a meta-analysis attempts to elucidate whether unipolar psychotic major depression (PMD) compared to non-PMD presents higher rates of suicides.
methodsA systematic search was conducted in Scopus, PubMed, and "gray literature" for all studies providing data on completed suicides in PMD compared to non-PMD, and the findings were then subjected to meta-analysis. All articles were independently extracted by two authors using predefined data fields.
resultsNine studies with 33,873 patients, among them 828 suicides, met our inclusion criteria. PMD compared to non-PMD presented a higher lifetime risk of completed suicides with fixed-effect pooled OR 1.21 (95% CI 1.04-1.40). In a sub-analysis excluding a very large study (weight = 86.62%), and comparing 681 PMD to 2106 non-PMD patients, an even higher pooled OR was found [fixed-effect OR 1.69 (95% CI 1.16-2.45)]. Our meta-analysis may provide evidence that the presence of psychosis increases the risk of suicide in patients suffering from severe depression. The data are inconclusive on the contribution of age, mood congruence, comorbidity, and suicide method on PMD's suicide risk. The lack of accurate diagnosis at the time of suicide, PMD's diagnostic instability, and the use of ICD-10 criteria constitute the main study limitations.
conclusionsThe presence of psychosis in major depression should alert clinicians for the increased risk of completed suicide. Thus, the implementation of an effective treatment both for psychotic depression and patients' suicidality constitutes a supreme priority.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.