Evidence map›Paper›PMID 30258470›Full record

ArticleNutrition & metabolism2018

Whole-body net protein balance plateaus in response to increasing protein intakes during post-exercise recovery in adults and adolescents.

Michael Mazzulla, Kimberly A Volterman, Jeff E Packer, Denise J Wooding, Jahmal C Brooks, Hiroyuki Kato, Daniel R Moore

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06256744 (Resistance Exercise-induced Anabolism in Youths and Adults), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06256744 narecruitingnot on this mapstarted 2024, after this paper: background citation

Resistance Exercise-induced Anabolism in Youths and Adults

TypeinterventionalSponsorBrock UniversityRan2024 to 2025Enrolled60ConditionsDietary Supplementation, ExerciseArmsexercise
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
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  7. Review
  8. Observational
  9. Nutritional Recommendations for the Young Athlete.Journal of the Pediatric Orthopaedic Society of North America · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Youth Athlete Development and Nutrition.Sports medicine (Auckland, N.Z.) · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Michael Mazzulla *1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.
Kimberly A Volterman *1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.
Jeff E Packer1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.
Denise J Wooding1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.
Jahmal C Brooks1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.
Hiroyuki Kato2Frontier Research Laboratories, Institute for Innovation, Ajinomoto Co., Inc, Kawasaki, Japan.
Daniel R Moore1Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON Canada.ORCID 0000-0001-5865-4398
University of Toronto · CAAjinomoto (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMuscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net balance to dietary protein. Moreover, limited research has addressed the anabolic response to dietary protein in adolescents. The present study determined whether whole-body net balance plateaued in response to increasing protein intakes during post-exercise recovery and whether there were age- and/or sex-related dimorphisms in the anabolic response.

methodsThirteen adults [7 males (M), 6 females (F)] and 14 adolescents [7 males (AM), 7 females (AF) within ~ 0.4 y from peak height velocity] performed ~ 1 h variable intensity exercise (i.e., Loughborough Intermittent Shuttle Test) prior to ingesting hourly mixed meals that provided a variable amount of protein (0.02-0.25 g·kg

resultsMixed model biphasic linear regression explained a greater proportion of net balance variance than linear regression (all,

conclusionsOur data suggest there is a practical limit to the anabolic response to protein ingestion within a mixed meal and that higher intakes lead to deamination and oxidation of excess amino acids. Consistent with a need to support lean mass growth, adolescents appear to have greater anabolic sensitivity and a greater capacity to assimilate dietary amino acids than adults.

Indexed as

Amino acidsAthleteGrowthLean body massMaximal anabolic responseMuscle protein synthesisPostprandialYouth

Identifiers

PMID30258470
PMCPMC6154919
OpenAlexW2890455599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.