Evidence map›Paper›PMID 30258437›Full record

Trial reportFrontiers in immunology2018

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults.

Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W Kazer, Pieter Jooste, Farina Karim and 9 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. CXCR5Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. TFrontiers in immunology · 2020
    Article
  16. Article
  17. The antibody response in HIV-1-infected donors.Current opinion in HIV and AIDS · 2019
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

Julia RoiderAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Takashi MaeharaRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States.
Abigail NgoepeAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Duran RamsuranAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Maximilian MuenchhoffDepartment of Virology, Max von Pettenkofer Institute, Ludwig-Maximilians-University Munich, Munich, Germany.
Emily AdlandDepartment of Paediatrics, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom.
Toby AicherRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States.
Samuel W KazerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States.
Pieter JoostePaediatric Department, Kimberley Hospital, Kimberley, South Africa.
Farina KarimAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Warren KuhnDepartment of Otorhinolaryngology, Stanger Hospital, KwaZulu-Natal, South Africa.
Alex K ShalekRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States.
Thumbi Ndung'uAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Lynn MorrisCentre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Penny L MooreCentre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Shiv PillaiRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States.
Henrik KløverprisAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Philip GoulderDepartment of Paediatrics, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom.
Alasdair LeslieAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
University of KwaZulu-Natal · ZAMassachusetts Institute of Technology · USUniversity College London · GBLudwig-Maximilians-Universität München · DENational Health Laboratory Service · ZARagon Institute of MGH, MIT and Harvard · USKimberley Hospital · ZAStanger Hospital · ZAUniversity of Oxford · GB

Funding

Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133673Wellcome Trust 202485/Z/16/Z
6 · The paper itself

Abstract

Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infection, since potent bnAbs develop with greater frequency in children than adults. As in adults, the frequency of circulating effector T-follicular helper cells (T

Indexed as

AdultAge FactorsAgingCD8-Positive T-LymphocytesChildFemaleGerminal CenterHIV-1HIV InfectionsHumansMaleT-Lymphocytes, Regulatorybroadly neutralizing antibodies (bnAb)follicular CD8 T-cellsgerminal centerpediatric HIV infectionT-follicular helper cells (Tfh)T-follicular regulatory helper cells (Tfreg)vaccination

Identifiers

PMID30258437
PMCPMC6143653
OpenAlexW2890697019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.