Evidence map›Paper›PMID 30258315›Full record

ReviewThe Yale journal of biology and medicine2018

Mechanistic Understanding of Single-Cell Behavior is Essential for Transformative Advances in Biomedicine.

Emmet A Francis, Volkmar Heinrich

Abstract readReview
In one paragraph

Review in The Yale journal of biology and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Intraphagosomal Free CaInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emmet A FrancisDepartment of Biomedical Engineering, University of California, Davis, Davis, CA.
Volkmar HeinrichDepartment of Biomedical Engineering, University of California, Davis, Davis, CA.

Funding

Cytoskeletal Membrane Anchors: Key Switchboards for Cellular Communication, MechaR01GM098060 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEINRICH, VOLKMAR · 2012 to 2015
$1.1M
NIGMS NIH HHS R01 GM098060
6 · The paper itself

Abstract

Most current efforts to advance medical technology proceed along one of two tracks. The first is dedicated to the improvement of clinical tasks through the incremental refinement of medical instruments. The second comprises engineering endeavors to support basic science studies that often only remotely relate to human medicine. Here we survey emerging research approaches that aim to populate the sprawling frontier between these tracks. We focus on interdisciplinary single-live-cell techniques that have overcome limitations of traditional biological methods to successfully address vital questions about medically relevant cellular behavior. Most of the presented case studies are based on the controlled manipulation of nonadherent human immune cells using one or more micropipettes. The included studies have

Indexed as

CalciumHost-Pathogen InteractionsHumansNeutrophilsPhagocytosisCalciumadhesioncalciumchemotaxishost-pathogenimmune cellmicropipetteneutrophilphagocytosissignalingsingle-cell

Identifiers

PMID30258315
PMCPMC6153630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.