Evidence map›Paper›PMID 30258225›Full record

ArticleNature2018

Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing.

Binbin Lai, Weiwu Gao, Kairong Cui, Wanli Xie, Qingsong Tang, Wenfei Jin, Gangqing Hu, Bing Ni, Keji Zhao

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 182 citations in OpenAlex.

  1. The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026
    Review
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  12. aBIOTECH · 2025
    Review
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Binbin LaiLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Weiwu GaoLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Kairong CuiLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Wanli XieLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Qingsong TangLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Wenfei JinDepartment of Biology, South University of Science and Technology of China, Shenzhen, China.
Gangqing HuLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Bing NiDepartment of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, China.
Keji ZhaoLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA. zhaok@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USArmy Medical University · CNSouthern University of Science and Technology · CN

Funding

Genome-wide mapping of histone modificationsZIAHL005801 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$24.0M
Epigenetic Regulation of Hematopoietic Stem CellsZIAHL006031 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$16.6M
Epigenetic Regulation of T cell differentiationZIAHL006030 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$15.3M
Intramural NIH HHS ZIA HL005801NHLBI NIH HHS
6 · The paper itself

Abstract

Nucleosome positioning is critical to chromatin accessibility and is associated with gene expression programs in cells

Indexed as

Gene SilencingSingle-Cell Analysis3T3 CellsAnimalsCD4-Positive T-LymphocytesCell DifferentiationCell LineageCells, CulturedDeoxyribonuclease IEnhancer Elements, GeneticEuchromatinGenomeHeterochromatinMaleMiceMicrococcal NucleaseDeoxyribonuclease IEuchromatinHeterochromatinMicrococcal NucleaseNucleosomes

Identifiers

PMID30258225
PMCPMC8353605
OpenAlexW2893467866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.