Evidence map›Paper›PMID 30258194›Full record

ArticleScientific reports2018

Molecular fingerprinting of nanoparticles in complex media with non-contact photoacoustics: beyond the light scattering limit.

Ivan Pelivanov, Elena Petrova, Soon Joon Yoon, Zhaoxia Qian, Kathryn Guye, Matthew O'Donnell

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ivan PelivanovDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA. ivanp3@uw.edu.
Elena PetrovaDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
Soon Joon YoonDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-2313-6678
Zhaoxia QianDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Kathryn GuyeDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0003-1684-8084
Matthew O'DonnellDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.

Funding

Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Nano-agent for photoacoustic theranostics of dialysis graft/fistula occlusionsR01HL125339 · NHLBI · UNIVERSITY OF WASHINGTON · PI POZZO, LILO D. · 2015 to 2019
$2.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NEI NIH HHS R01 EY026532NHLBI NIH HHS R01 HL125339NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

Optical instruments can probe physical systems even to the level of individual molecules. In particular, every molecule, solution, and structure such as a living cell has a unique absorption spectrum representing a molecular fingerprint. This spectrum can help identify a particular molecule from others or quantify its concentration; however, scattering limits molecular fingerprinting within a complex compound and must be overcome. Here, we present a new, non-contact photoacoustic (PA)-based method that can almost completely remove the influence of background light scattering on absorption measurements in heterogeneous highly scattering solutions and, furthermore, separate the intrinsic absorption of nanoscale objects from their scattering. In particular, we measure pure absorption spectra for solutions of gold nanorods (GNRs) as an example of a plasmonic agent and show that these spectra differ from the extinction measured with conventional UV-VIS spectrophotometry. Finally, we show how the original GNR absorption changes when nanoparticles are internalized by cells.

Indexed as

Dynamic Light ScatteringEquipment DesignGoldHumansHuman Umbilical Vein Endothelial CellsNanotubesParticle SizePhotoacoustic TechniquesSpectrophotometry, UltravioletGold

Identifiers

PMID30258194
PMCPMC6158233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.