ArticleNature communications2018
Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Negative feedback regulation of karrikin signaling inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The genome of Thesium ramosoides (Santalales) reveals evolutionary dynamics associated with parasitism and alpine adaptation.Plant communications · 2026Article
- Potent and Receptor-Selective Germination Inhibitor forPrecision chemistry · 2026Article
- Divergent strigolactones or karrikins signaling is mediated by preferred AtD14/KAI2-MAX2-SMXL complex targeting specific SMXL domains.iScience · 2026Article
- Mapping Strigolactone Hydrolysis in DWARF14 via QM/MM String Method.bioRxiv : the preprint server for biology · 2026Article
- Strigolactones and sesquiterpene lactones induce Orobanche cumana germination via KAI2d receptors through distinct processes.The Plant journal : for cell and molecular biology · 2026Article
- Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026Review
- Overexpression of DWARF14-LIKE2 in Arabidopsis thaliana alters multiple traits related to plant morphology and osmotic and salt stress tolerance.Plant cell reports · 2026Article
- Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase-receptor-substrate complex.Nature communications · 2025Article
- The Multifaceted Impact of Karrikin Signaling in Plants.International journal of molecular sciences · 2025Review
- Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling.Nature communications · 2025Article
- Article
- Cracking the enigma: understanding strigolactone signalling in the rhizosphere.Journal of experimental botany · 2024Review
- Karrikin signalling: impacts on plant development and abiotic stress tolerance.Journal of experimental botany · 2024Article
- Role of Strigolactones in the Host Specificity of Broomrapes and Witchweeds.Plant & cell physiology · 2023Review
- A Divergent Clade KAI2 Protein in the Root Parasitic Plant Orobanche minor Is a Highly Sensitive Strigolactone Receptor and Is Involved in the Perception of Sesquiterpene Lactones.Plant & cell physiology · 2023Article
- Effect of histidine covalent modification on strigolactone receptor activation and selectivity.Biophysical journal · 2023Article
- Strigolactones: diversity, perception, and hydrolysis.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2023Article
- Individual and combined effects of arbuscular mycorrhizal fungi and phytohormones on the growth and physiobiochemical characteristics of tea cutting seedlings.Frontiers in plant science · 2023Article
- Strigol induces germination of the facultative parasitic plantPlant signaling & behavior · 2022Article
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Authors and funding
11 authors.
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Abstract
HYPOSENSITIVE TO LIGHT (HTL) and DWARF14 (D14) mediate the perception of karrikin and strigolactone, which stimulates germination of the parasitic weed Striga. However, their role in parasitic seeds is poorly understood, and the basis for their differing responsiveness remains unclear. Here, we show that Striga hermonthica HTL proteins (ShHTLs) in 'conserved' and 'intermediate' clades are able to bind karrikin. The 'divergent' clade is able to hydrolyze strigolactone. Unexpectedly, we find that ShD14 is also capable of hydrolyzing strigolactone. Through comparative analysis of ShHTLs and ShD14 crystal structures, we provide insights into the basis for their selectivity. Moreover, we show that both ShD14 and divergent clade ShHTLs, but not conserved and intermediate clade ShHTLs, can interact with the putative downstream signaling component ShMAX2 in the presence of the synthetic strigolactone, rac-GR24. These findings provide insight into how strigolactone is perceived and how ligand specificity is determined.
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