ArticleScientific reports2018
A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Directed evolution of a cytochrome P450 monooxygenase for improved perillyl alcohol biosynthesisRSC advances · 2026Article
- Solid-state platform (SSP) to produce terpenes from enzymatically treated textile waste withRSC advances · 2026Article
- Production of derivatives of α-terpineol by bacterial CYP102A1 enzymes.Biotechnology letters · 2024Article
- Structural Insights into the Interaction of Terpenoids withBiomolecules & therapeutics · 2024Article
- Production of Mono-Hydroxylated Derivatives of Terpinen-4-ol by Bacterial CYP102A1 Enzymes.Journal of microbiology and biotechnology · 2024Article
- Differential RNA-Seq Analysis Predicts Genes Related to Terpene Tailoring inPlants (Basel, Switzerland) · 2023Article
- The deterrent effects of individual monoterpene odours on the dietary decisions of African elephants.Animal cognition · 2023Article
- Comparative Genome-Wide Analysis of TwoPlants (Basel, Switzerland) · 2023Article
- Enzymatic Hydrolysis of Textile and Cardboard Waste as a Glucose Source for the Production of Limonene inLife (Basel, Switzerland) · 2022Article
- Synthetic utility of oxygenases in site-selective terpenoid functionalization.Journal of industrial microbiology & biotechnology · 2021Review
- Identification of Fungal Limonene-3-Hydroxylase for Biotechnological Menthol Production.Applied and environmental microbiology · 2021Article
- Diversifying Isoprenoid PlatformsFrontiers in microbiology · 2021Review
- Current Advances in the Bacterial Toolbox for the Biotechnological Production of Monoterpene-Based Aroma Compounds.Molecules (Basel, Switzerland) · 2020Review
- Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids.Journal of industrial microbiology & biotechnology · 2020Review
- Divergent synthesis of complex diterpenes through a hybrid oxidative approach.Science (New York, N.Y.) · 2020Article
- An automated pipeline for the screening of diverse monoterpene synthase libraries.Scientific reports · 2019Article
- Preferences of Specialist and Generalist Mammalian Herbivores for Mixtures Versus Individual Plant Secondary Metabolites.Journal of chemical ecology · 2019Article
- Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering.Beilstein journal of organic chemistry · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The successful implementation of synthetic biology for chemicals biosynthesis relies on the availability of large libraries of well-characterized enzymatic building blocks. Here we present a scalable pipeline that applies the methodology of synthetic biology itself to bootstrap the creation of such a library. By designing and building a cytochrome P450 enzyme collection and testing it in a custom-made untargeted GC/MS-metabolomics-based approach, we were able to rapidly create and characterize a comprehensive enzyme library for the controlled oxyfunctionalisation of terpene scaffolds with a wide range of activities and selectivities towards several monoterpenes. This novel resource can now be used to access the extensive chemical diversity of terpenoids by pathway engineering and the assembly of biocatalytic cascades to subsequently produce libraries of oxygenated terpenoids and their derivatives for diverse applications, including drug discovery.
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Registered trials
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