ArticleHeredity2019
Selection, drift, and introgression shape MHC polymorphism in lizards.
Article in Heredity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Intra-colony divergence and global allele sharing reflect purifying selection and recombination at the Botryllus histocompatibility factor locus.Immunogenetics · 2026Article
- Article
- Immunogenetic-pathogen networks shrink in Tome's spiny rat, a generalist rodent inhabiting disturbed landscapes.Communications biology · 2024Article
- Evolution of MHC IIB Diversity Across Cichlid Fish Radiations.Genome biology and evolution · 2023Review
- Diversifying selection and climatic effects on major histocompatibility complex class II gene diversity in the greater horseshoe bat.Evolutionary applications · 2023Article
- Interspecific introgression of MHC genes in Triturus newts: Evidence from multiple contact zones.Molecular ecology · 2023Article
- Adaptive evolution of major histocompatibility complex class I immune genes and disease associations in coastal juvenile sea turtles.Royal Society open science · 2022Article
- Balancing selection versus allele and supertype turnover in MHC class II genes in guppies.Heredity · 2021Article
- Habitat fragmentation differentially shapes neutral and immune gene variation in a tropical bird species.Heredity · 2021Article
- Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The major histocompatibility complex (MHC) has long served as a model for the evolution of adaptive genetic diversity in wild populations. Pathogen-mediated selection is thought to be a main driver of MHC diversity, but it remains elusive to what degree selection shapes MHC diversity in complex biogeographical scenarios where other evolutionary processes (e.g. genetic drift and introgression) may also be acting. Here we focus on two closely related green lizard species, Lacerta trilineata and L. viridis, to address the evolutionary forces acting on MHC diversity in populations with different biogeographic structure. We characterized MHC class I exon 2 and exon 3, and neutral diversity (microsatellites), to study the relative importance of selection, drift, and introgression in shaping MHC diversity. As expected, positive selection was a significant force shaping the high diversity of MHC genes in both species. Moreover, introgression significantly increased MHC diversity in mainland populations, with a primary direction of gene flow from L. viridis to L. trilineata. Finally, we found significantly fewer MHC alleles in island populations, but maintained MHC sequence and functional diversity, suggesting that positive selection counteracted the effect of drift. Overall, our data support that different evolutionary processes govern MHC diversity in different biogeographical scenarios: positive selection occurs broadly while introgression acts in sympatry and drift when the population sizes decrease.
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