SynthesisScientific reports2018
Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial "spaceflight response".
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Comparison ofMicrobiology (Reading, England) · 2026Article
- Rotifers in space: transcriptomic response of the bdelloid rotifer Adineta vaga aboard the International Space Station.BMC biology · 2025Article
- Whole genome-scale assessment of gene fitness of Novosphingobium aromaticavorans during spaceflight.BMC genomics · 2023Article
- Microgravity and evasion of plant innate immunity by human bacterial pathogens.NPJ microgravity · 2023Review
- One Step Forward with Dry Surface Biofilm (DSB) ofInternational journal of molecular sciences · 2022Article
- Simulated Micro-, Lunar, and Martian Gravities on Earth-Effects onLife (Basel, Switzerland) · 2022Article
- CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity.Life (Basel, Switzerland) · 2022Article
- Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation.Life (Basel, Switzerland) · 2021Article
- Clinostat Rotation Affects Metabolite Transportation and Increases Organic Acid Production byApplied and environmental microbiology · 2019Article
- Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft.MicrobiologyOpen · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Several studies have been undertaken with the goal of understanding how bacterial transcriptomes respond to the human spaceflight environment. However, these experiments have been conducted using a variety of organisms, media, culture conditions, and spaceflight hardware, and to date no cross-experiment analyses have been performed to uncover possible commonalities in their responses. In this study, eight bacterial transcriptome datasets deposited in NASA's GeneLab Data System were standardized through a common bioinformatics pipeline then subjected to meta-analysis to identify among the datasets (i) individual genes which might be significantly differentially expressed, or (ii) gene sets which might be significantly enriched. Neither analysis resulted in identification of responses shared among all datasets. Principal Component Analysis of the data revealed that most of the variation in the datasets derived from differences in the experiments themselves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.