ArticleScientific reports2018
Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Rewiring Amino Acid Flux for Efficient Transglutaminase Production inJournal of agricultural and food chemistry · 2026Article
- Analysis of Short-Term Responses to Hypoxia During Stirred-Tank Fermentation inJournal of fungi (Basel, Switzerland) · 2026Article
- Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant.Biotechnology and bioengineering · 2025Article
- Adjusting Aspergillus niger pellet diameter, population heterogeneity, and core architecture during shake flask cultivation.Biotechnology for biofuels and bioproducts · 2025Article
- MINN: A metabolic-informed neural network for integrating omics data into genome-scale metabolic modeling.Computational and structural biotechnology journal · 2025Article
- Deep longitudinal multi-omics analysis ofFrontiers in microbiology · 2023Article
- Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger.Microbial cell factories · 2022Article
- Cephalosporin C biosynthesis and fermentation in Acremonium chrysogenum.Applied microbiology and biotechnology · 2022Review
- Article
- Assessing the intracellular primary metabolic profile ofFrontiers in fungal biology · 2022Article
- Exploration and characterization of hypoxia-inducible endogenous promoters in Aspergillus niger.Applied microbiology and biotechnology · 2021Article
- Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions.Microbial cell factories · 2021Article
- Genetic Manipulation and Transformation Methods forMycobiology · 2021Review
- Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger.Microbial cell factories · 2020Article
- Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation.Microbial cell factories · 2020Article
- Multi-omics Comparative Analysis ofFrontiers in microbiology · 2020Article
- Harnessing microbial metabolomics for industrial applications.World journal of microbiology & biotechnology · 2019Review
- Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain ofFrontiers in bioengineering and biotechnology · 2019Article
- Rewiring of Metabolic Network inFrontiers in microbiology · 2019Article
- Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres inFungal biology and biotechnology · 2019Article
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11 authors.
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Abstract
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of A. niger was studied using multi-omics integrated analysis based on the latest GEMs (genome-scale metabolic model), including metabolomics, fluxomics and transcriptomics. Upon sharp reduction of the oxygen supply, A. niger metabolism shifted to higher redox level status, as well as lower energy supply, down-regulation of genes for fatty acid synthesis and a rapid decrease of the specific growth rate. The gene expression of the glyoxylate bypass was activated, which was consistent with flux analysis using the A. niger GEMs iHL1210. The increasing flux of the glyoxylate bypass was assumed to reduce the NADH formation from TCA cycle and benefit maintenance of the cellular redox balance under hypoxic conditions. In addition, the relative fluxes of the EMP pathway were increased, which possibly relieved the energy demand for cell metabolism. The above multi-omics integrative analysis provided new insights on metabolic regulatory mechanisms of A. niger associated with enzyme production under oxygen-limited condition, which will benefit systematic design and optimization of the A. niger microbial cell factory.
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