SynthesisNature communications2018
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias.Nature genetics · 2026Pooled it
- GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.Nature communications · 2026Pooled it
- A systematic review of non-coding RNA genes with differential expression profiles associated with autism spectrum disorders.PloS one · 2023Pooled it
- Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.Acta neuropathologica · 2022Pooled it
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins.medRxiv : the preprint server for health sciences · 2026Article
- From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus.Journal of neurology, neurosurgery, and psychiatry · 2026Review
- Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia.medRxiv : the preprint server for health sciences · 2025Article
- Integration of Genetic Information to Improve Brain Age Gap Estimation Models in the UK Biobank.Human brain mapping · 2025Article
- Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI.Nature communications · 2025Article
- HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer's disease.Nature communications · 2025Article
- Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.medRxiv : the preprint server for health sciences · 2025Article
- Molecular hallmarks of hydrocephalus.Science translational medicine · 2025Review
- Genome-wide association study unravels mechanisms of brain glymphatic activity.Nature communications · 2025Article
- Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment.Frontiers in neurology · 2025Article
- Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.Nature genetics · 2024Article
- Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.Neurology · 2024Article
- Genetic variants for head size share genes and pathways with cancer.Cell reports. Medicine · 2024Article
- Longitudinal assessment of ventricular volume trajectories in early-stage schizophrenia: evidence of both enlargement and shrinkage.BMC psychiatry · 2024Article
- The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
91 authors.
Dina VojinovicDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands. d.vojinovic@erasmusmc.nl.
Hieab H AdamsDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Xueqiu JianThe University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.
Qiong YangDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.ORCID http://orcid.org/0000-0002-3658-1375
Albert Vernon SmithIcelandic Heart Association, Kopavogur 201, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig 04107, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, WA 6150, Australia.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz 8036, Austria.
Yasaman SabaGottfried Schatz research center, Institute for Molecular biology and biochemistry, Graz 8010, Austria.
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-7306-3008
Manon BernardResearch Institute of the Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23284, USA.
Sven J van der LeeDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Alexander NeumannDepartment of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam, Rotterdam 3000 CB, The Netherlands.ORCID http://orcid.org/0000-0001-6653-3203
Shahzad AhmadDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo 0372, Norway.ORCID http://orcid.org/0000-0002-4461-3568
David AmesNational Ageing Research Institute, Melbourne, VIC 3052, Australia.
Najaf AminDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
Konstantinos ArfanakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Mark E BastinCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Diane M BeckerDivision of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Alexa S BeiserDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.
Frauke BeyerDepartment of Neurology, Max Planck Institute of Cognitive and Brain Sciences, Leipzig 04103, Germany.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, UNSW, Sydney, NSW 2052, Australia.ORCID http://orcid.org/0000-0001-9487-6617
R Nick BryanThe University of Texas at Austin Dell Medical School, Austin, TX 78705, USA.
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald 17475, Germany.
Anders M DaleDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA.
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.ORCID http://orcid.org/0000-0002-8057-2505
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Charles DeCarliDepartment of Neurology and Center for Neuroscience, University of California, Davis, CA 95817, USA.
Debra A FleischmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Jeroen van der GrondDepartment of Radiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
John B KwokSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Cora E LewisThe University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.
Shuo LiDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.ORCID http://orcid.org/0000-0003-2331-2448
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig 04107, Germany.
Oscar L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Pauline MaillardDepartment of Neurology and Center for Neuroscience, University of California, Davis, CA 95817, USA.
Hanan El MarrounDepartment of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam, Rotterdam 3000 CB, The Netherlands.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, UNSW, Sydney, NSW 2052, Australia.
Thomas H MosleyThe University of Mississippi Medical Center, Jackson, MS 39216, USA.
Ryan L MuetzelDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Paul A NyquistDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
Zdenka PausovaResearch Institute of the Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Ken RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Natalie RoyleCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Claudia L SatizabalFramingham Heart Study, Framingham, MA 01702, USA.ORCID http://orcid.org/0000-0002-1115-4430
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz 8036, Austria.
Peter R SchofieldSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Pamela J SchreinerUniversity of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
Stephen SidneyKaiser Permanente Northern California Division of Research, Oakland, CA 94612, USA.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, UNSW, Sydney, NSW 2052, Australia.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam 3015, The Netherlands.
Maria C Valdés HernándezCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, UNSW, Sydney, NSW 2052, Australia.
Tonya WhiteDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
A Veronica WitteDepartment of Neurology, Max Planck Institute of Cognitive and Brain Sciences, Leipzig 04103, Germany.
Katharina WittfeldGerman Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald 17475, Germany.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Lisa R YanekDivision of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Center Rotterdam, Rotterdam 3000 CB, The Netherlands.ORCID http://orcid.org/0000-0002-4395-1397
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Tomas PausRotman Research Institute, Baycrest, Toronto, Ontario M6A 2E1, Canada.
Joanna M WardlawCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-9812-6642
Helena SchmidtGottfried Schatz research center, Institute for Molecular biology and biochemistry, Graz 8010, Austria.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, UNSW, Sydney, NSW 2052, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Arno VillringerDepartment of Neurology, Max Planck Institute of Cognitive and Brain Sciences, Leipzig 04103, Germany.
Hans Jörgen GrabeGerman Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald 17475, Germany.ORCID http://orcid.org/0000-0003-3684-4208
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA 98195, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Sudha SeshadriFramingham Heart Study, Framingham, MA 01702, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3015 CN, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Myriam FornageThe University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA. Myriam.Fornage@uth.tmc.edu.
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JOHNSON, DAVID K · 1991 to 2020
$28.3MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541
Abstract
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρ
Indexed as
Genome, HumanAgedGenome-Wide Association StudyHumansLateral VentriclesMiddle AgedOrgan Size
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