Evidence map›Paper›PMID 30258037›Full record

ArticlemSphere2018

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death.

Yinghui Rong, Jennifer Westfall, Dylan Ehrbar, Timothy LaRocca, Nicholas J Mantis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yinghui RongDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Jennifer WestfallDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Dylan EhrbarDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Timothy LaRoccaDepartment of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, USA Timothy.LaRocca@acphs.edu nicholas.mantis@health.ny.gov.
Nicholas J MantisDivision of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA Timothy.LaRocca@acphs.edu nicholas.mantis@health.ny.gov.ORCID 0000-0002-5083-8640
New York State Department of Health · USAlbany College of Pharmacy and Health Sciences · US

Funding

NIAID NIH HHS HHSN272201400021C
6 · The paper itself

Abstract

Inhalation of ricin toxin is associated with the onset of acute respiratory distress syndrome (ARDS), characterized by hemorrhage, inflammatory exudates, and tissue edema, as well as the nearly complete destruction of the lung epithelium. Here we report that the Calu-3 human airway epithelial cell line is relatively impervious to the effects of ricin, with little evidence of cell death even upon exposure to microgram amounts of toxin. However, the addition of exogenous soluble

Indexed as

A549 CellsApoptosisCell Line, TumorCytokinesEpithelial CellsHumansInflammationInterleukin-6LungRicinSignal TransductionTNF-Related Apoptosis-Inducing LigandCytokinesIL6 protein, humanInterleukin-6RicinTNF-Related Apoptosis-Inducing Ligandbioterrorismcytokinesepithelial cellsinflammationlung defensetoxins

Identifiers

PMID30258037
PMCPMC6158510
OpenAlexW2951604748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.