ArticleJournal of virology2018
Comparison of the Immunogenicities and Cross-Lineage Efficacies of Live Attenuated Peste des Petits Ruminants Virus Vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96.
Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Epidemiology of Peste des Petits Ruminants in Nigeria: A Review.Frontiers in veterinary science · 2022Pooled it
- Integrating Epidemiology, Immunology, and Host Genetics for Controlling Peste des Petits Ruminants in Goats.Viruses · 2026Review
- Age-Related Immune Responses and Long-Term Immunity in Adult Sheep and Goats Following Vaccination with the Nigeria 75/1 Live Attenuated PPR Vaccine.Veterinary sciences · 2026Article
- Epidemiological and Operational Constraints on the Feasibility of Peste des Petits Ruminants Eradication Target by 2030: Necessity for a New Pragmatic Road Map.Transboundary and emerging diseases · 2026Review
- Genetic analyses and functional validation of ruminant SLAMs reveal potential hosts for PPRV.Veterinary research · 2025Article
- Assessment of peste des petits ruminant's vaccine wastage along the vaccine supply chain in Mali.Frontiers in veterinary science · 2025Article
- Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein.NPJ vaccines · 2024Article
- Molecular Epidemiology of Peste Des Petits Ruminants Virus in West Africa: Is Lineage IV Replacing Lineage II in Burkina Faso?Viruses · 2024Article
- Can the Revolution in mRNA-Based Vaccine Technologies Solve the Intractable Health Issues of Current Ruminant Production Systems?Vaccines · 2024Review
- Article
- Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages.Virus evolution · 2024Article
- Article
- A recombinant capripoxvirus expressing the F protein of peste des petits ruminants virus and the P12A3C of foot-and-mouth disease virus.BMC veterinary research · 2023Article
- Free ISG15 Inhibits the Replication of Peste des Petits Ruminants Virus by Breaking the Interaction of Nucleoprotein and Phosphoprotein.Microbiology spectrum · 2022Article
- Genomic characterization of peste des petits ruminants vaccine seed "45G37/35-k", Russia.Veterinary research · 2022Article
- Peste des Petits Ruminants in Central and Eastern Asia/West Eurasia: Epidemiological Situation and Status of Control and Eradication Activities after the First Phase of the PPR Global Eradication Programme (2017-2021).Animals : an open access journal from MDPI · 2022Review
- Research Progress on Emerging Viral Pathogens of Small Ruminants in China during the Last Decade.Viruses · 2022Review
- Systematic Determination of TCR-Antigen and Peptide-MHC Binding Kinetics among Field Variants of aJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Depletion of CD8Transboundary and emerging diseases · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East, and Asia. Several effective vaccines exist for the disease, based on attenuated strains of the virus (PPRV) that causes PPR. While the efficacy of these vaccines has been established by use in the field, the nature of the protective immune response has not been determined. In addition, while the vaccine derived from PPRV/Nigeria/75/1 (N75) is used in many countries, those developed in India have never been tested for their efficacy outside that country. We have studied the immune response in goats to vaccination with either N75 or the main Indian vaccine, which is based on isolate PPRV/India/Sungri/96 (S96). In addition, we compared the ability of these two vaccines, in parallel, to protect animals against challenge with pathogenic viruses from the four known genetic lineages of PPRV, representing viruses from different parts of Africa, as well as Asia. These studies showed that, while N75 elicited a stronger antibody response than S96, as measured by both enzyme-linked immunosorbent assay and virus neutralization, S96 resulted in more pronounced cellular immune responses, as measured by virus antigen-induced proliferation and interferon gamma production. While both vaccines induced comparable numbers of PPRV-specific CD8
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.