Evidence map›Paper›PMID 30257992›Full record

ArticleMolecular cancer research : MCR2019

TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions.

Brook S Nepon-Sixt, Mark G Alexandrow

Abstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Brook S Nepon-SixtDepartment of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
Mark G AlexandrowDepartment of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida. Mark.Alexandrow@Moffitt.org.
Moffitt Cancer Center · USMolecular Oncology (United States) · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Chromatin Remodeling by Cdt1: Role in DNA Replication and TumorigenesisR01CA130865 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2010 to 2014
$1.5M
Inhibition of the CMG Helicase as Novel Anti-Neoplastic ApproachR21CA187513 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2016 to 2017
$407k
MCM Helicase as a Novel Target for Pancreatic Cancer TreatmentR21CA155393 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ALEXANDROW, MARK G. · 2011 to 2012
$400k
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA130865NCI NIH HHS R21 CA155393NCI NIH HHS R21 CA187513
6 · The paper itself

Abstract

Transforming growth factor β1 (TGFβ1) is a potent inhibitor of cell growth that targets gene-regulatory events, but also inhibits the function of CDC45-MCM-GINS helicases (CMG; MCM, Mini-Chromosome Maintenance; GINS, Go-Ichi-Ni-San) through multiple mechanisms to achieve cell-cycle arrest. Early in G

Indexed as

AnimalsCell Cycle CheckpointsHumansKeratinocytesMiceMice, Inbred BALB CMinichromosome Maintenance Complex Component 2Minichromosome Maintenance Complex Component 7Minichromosome Maintenance ProteinsRecombinant ProteinsRetinoblastoma ProteinTransfectionTransforming Growth Factor beta1Mcm2 protein, mouseMcm7 protein, mouseMinichromosome Maintenance Complex Component 2Minichromosome Maintenance Complex Component 7Minichromosome Maintenance ProteinsRecombinant ProteinsRetinoblastoma ProteinTGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID30257992
PMCPMC6318023
OpenAlexW2893890434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.