ArticleScience translational medicine2018
Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome.
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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0cells of the map it votes in
56citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 79 citations in OpenAlex.
- Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation.Genome medicine · 2026Article
- Prelamin A in anArteriosclerosis, thrombosis, and vascular biology · 2026Article
- Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153.Journal of cell science · 2026Article
- Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations?Medical sciences (Basel, Switzerland) · 2025Review
- Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease.Nucleus (Austin, Tex.) · 2025Review
- Attenuated Nuclear Tension Regulates Progerin-Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome.Cell death & disease · 2025Article
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease.Nature aging · 2025Article
- Mechanisms of aging in the cardiovascular system: challenges and opportunities.Frontiers in immunology · 2025Review
- Cardiac and skeletal muscle manifestations in the G608G mouse model of Hutchinson-Gilford progeria syndrome.Aging cell · 2024Article
- Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome.The Journal of cell biology · 2024Article
- Mechanotransduction of the vasculature in Hutchinson-Gilford Progeria Syndrome.Frontiers in physiology · 2024Review
- Prelamin A and ZMPSTE24 in premature and physiological aging.Nucleus (Austin, Tex.) · 2023Review
- Revisiting the truncated lamin A produced by a commonly used strain ofNucleus (Austin, Tex.) · 2023Article
- Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria.Biomechanics and modeling in mechanobiology · 2023Article
- Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction.Biochemical Society transactions · 2023Review
- Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Paul H KimDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8429-651X
Jennings LuuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-7283-0335
Patrick HeizerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yiping TuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thomas A WestonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-3720-8633
Natalie ChenDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Christopher LimDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Robert L LiDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5433-5055
Po-Yu LinDepartment of Surgery, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
James C Y DunnDepartment of Surgery, Stanford University School of Medicine, Palo Alto, CA 94305, USA.ORCID 0000-0002-6826-7065
Didier HodzicDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stephen G YoungDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. lfong@mednet.ucla.edu sgyoung@mednet.ucla.edu.ORCID 0000-0001-7270-3176
Loren G FongDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. lfong@mednet.ucla.edu sgyoung@mednet.ucla.edu.
University of California, Los Angeles · USPalo Alto University · USWashington University in St. Louis · US
Funding
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0MCaaX Protein Processing and Human DiseaseR01AG035626 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2009 to 2013
$2.0MZMPSTE24, HIV treatment regimens, and atherosclerotic heart diseaseR01HL126551 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2014 to 2017
$1.8MDevelopment of a New Therapeutic Approach for Prelamin A DiseasesR01AG047192 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2014 to 2018
$1.6MNHLBI NIH HHS R01 HL126551NIA NIH HHS R01 AG035626NIA NIH HHS R01 AG047192NIDDK NIH HHS P30 DK041301
Abstract
Hutchinson-Gilford progeria syndrome is a disorder of premature aging in children caused by de novo mutations in
Indexed as
AdventitiaAnimalsAortaAortic DiseasesCell DeathCells, CulturedCollagen Type VIIIDisease Models, AnimalLamin Type ALamin Type BMiceMultiprotein ComplexesMyocytes, Smooth MusclePhenotypeProgeriaCollagen Type VIIILamin Type ALamin Type BMultiprotein Complexesprelamin A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.