Evidence map›Paper›PMID 30257946›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

IL-15 regulates susceptibility of CD4

Lara Manganaro, Patrick Hong, Matthew M Hernandez, Dionne Argyle, Lubbertus C F Mulder, Uma Potla, Felipe Diaz-Griffero, Benhur Lee, Ana Fernandez-Sesma, Viviana Simon

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation.International journal of molecular sciences · 2025
    Review
  7. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Advances in HIV Research Using Mass Cytometry.Current HIV/AIDS reports · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lara ManganaroDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; manganaro@ingm.org viviana.simon@mssm.edu.
Patrick HongDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Matthew M HernandezDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Dionne ArgyleDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Lubbertus C F MulderDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Uma PotlaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Felipe Diaz-GrifferoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Benhur LeeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-0760-1709
Ana Fernandez-SesmaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-3405-6702
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; manganaro@ingm.org viviana.simon@mssm.edu.
Icahn School of Medicine at Mount Sinai · USAlbert Einstein College of Medicine · USIstituto Nazionale Genetica Molecolare · IT

Funding

Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FERNANDEZ-SESMA, ANA · 2015 to 2021
$46.6M
Preventing CD4+ T memory cells from becoming HIV reservoirsR01AI136916 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIMON, VIVIANA A · 2018 to 2021
$2.4M
HIV restriction by APOBEC3AR01AI120998 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIMON, VIVIANA A · 2016 to 2020
$2.4M
Impact of HERV-K expression on HIV-1 life cycleR01GM113886 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, LUBBERTUS C · 2014 to 2018
$1.8M
Targeting HIV persistence in CD4+ T memory stem cellsR56AI125173 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIMON, VIVIANA A · 2016 to 2016
$424k
NIAID NIH HHS R01 AI120998NIAID NIH HHS R01 AI136916NIAID NIH HHS R56 AI125173NIAID NIH HHS U19 AI118610NIGMS NIH HHS R01 GM113886
6 · The paper itself

Abstract

HIV integrates into the host genome to create a persistent viral reservoir. Stimulation of CD4

Indexed as

CD4-Positive T-LymphocytesDisease SusceptibilityFemaleHEK293 CellsHIV-1HIV InfectionsHumansInterleukin-15Janus Kinase 1Janus Kinase 2MaleMemory, Short-TermNitrilesPyrazolesPyrimidinesSAM Domain and HD Domain-Containing Protein 1IL15 protein, humanInterleukin-15JAK1 protein, humanJAK2 protein, humanJanus Kinase 1Janus Kinase 2NitrilesPyrazolesPyrimidinesruxolitinibSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanCD4 T memory stem cellsHIVIL-15SAMHD1

Identifiers

PMID30257946
PMCPMC6187195
OpenAlexW2893301364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.