Evidence map›Paper›PMID 30257928›Full record

ArticleThe Journal of general physiology2018

Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion.

Jarred M Whitlock, Kuai Yu, Yuan Yuan Cui, H Criss Hartzell

Abstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Sex differences in the involvement of skeletal and cardiac muscles in myopathicAmerican journal of physiology. Cell physiology · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. How Do Cancer Cells Fuse and Why?Advances in experimental medicine and biology · 2026
    Review
  6. Article
  7. Review
  8. Cell-cell fusion: To lose one life and begin another.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Cell Fusion and Syncytia Formation in Cancer.Results and problems in cell differentiation · 2024
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jarred M WhitlockDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-5886-2047
Kuai YuDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA.
Yuan Yuan CuiDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA.
H Criss HartzellDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA criss.hartzell@emory.edu.ORCID 0000-0002-3393-1528

Funding

Retinal Degeneration and Chloride ChannelsR01EY014852 · NEI · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2003 to 2020
$5.7M
Molecular Physiology of TMEM16/Anoctamin ProteinsR01GM132598 · NIGMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2019 to 2022
$1.5M
Ion Channel and Lipid Scramblase Functions of Anoctamins: Roles in MyopathyR01AR067786 · NIAMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2015 to 2018
$1.4M
The Role of Anoctamin 6 in Phospholipid Scrambling and Ion Channel ActivityF31GM116556 · NIGMS · EMORY UNIVERSITY · PI WHITLOCK, JARRED MARCUS · 2016 to 2018
$100k
NEI NIH HHS R01 EY014852NIAMS NIH HHS R01 AR067786NIGMS NIH HHS F31 GM116556NIGMS NIH HHS R01 GM132598
6 · The paper itself

Abstract

Limb-girdle muscular dystrophy type 2L (LGMD2L) is a myopathy arising from mutations in

Indexed as

AnimalsAnoctaminsCalciumHEK293 CellsHumansMiceMyoblastsPhosphatidylserinesPhospholipid Transfer ProteinsANO5 protein, humanAnoctaminsCalciumPhosphatidylserinesPhospholipid Transfer Proteins

Identifiers

PMID30257928
PMCPMC6219693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.