ArticlePediatrics2018
Epigenetic Programming by Maternal Behavior in the Human Infant.
Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Early childhood stress responses to psychosocial stressors: The state of the science.Developmental psychobiology · 2022Pooled it
- Parenting as a Mediator of Associations between Depression in Mothers and Children's Functioning: A Systematic Review and Meta-Analysis.Clinical child and family psychology review · 2020Pooled it
- Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age.The American journal of clinical nutrition · 2022Trial
- Epigenome-Wide Association of Infant Feeding and Changes in DNA Methylation from Birth to 10 Years.Nutrients · 2020Trial
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- Exclusively Pumping Women's Milk Production and Pumping and Feeding Dynamics-An Online Survey.Healthcare (Basel, Switzerland) · 2026Article
- Study Protocol for a Randomized Controlled Trial of Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants: Enhancing Stress Regulation, Neurodevelopment, and Oral Feeding Skills.Biological research for nursing · 2026Article
- Pumps, patriarchy, and profits: the rise of breast pumping and "human milk feeding" and why preserving "breastfeeding" is important.International breastfeeding journal · 2026Article
- Early Life Stress, DNA Methylation of NR3C1 and HSD11B2 , and Oral Feeding Skill Development in Preterm Infants : A Pilot Study.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2025Article
- Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.Frontiers in epigenetics and epigenomics · 2025Article
- Epigenetics Embedding of Oral Feeding Skill Development in Preterm Infants: A Study Protocol.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2024Article
- Affective Touch in Preterm Infant Development: Neurobiological Mechanisms and Implications for Child-Caregiver Attachment and Neonatal Care.Children (Basel, Switzerland) · 2024Review
- Infant emotion regulation in the context of stress: Effects of heart rate variability and temperament.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Examining the Biological Impacts of Parent-Child Relationship Dynamics on Preschool-Aged Children who have Experienced Adversity.Developmental psychobiology · 2024Observational
- The Yin and Yang of the oxytocin and stress systems: opposites, yet interdependent and intertwined determinants of lifelong health trajectories.Frontiers in endocrinology · 2024Article
- Article
- Adverse Childhood Experiences and Developmental Delay in Young US Children.Maternal and child health journal · 2024Article
- Exposure to prenatal stressors and infant autonomic nervous system regulation of stress.Stress (Amsterdam, Netherlands) · 2024Article
- Breastfeeding: science and knowledge in pediatric obesity prevention.Frontiers in medicine · 2024Article
- Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
: media-1vid110.1542/5804912859001PEDS-VA_2017-1890
methodsA cohort study of term, healthy infants and their mothers who did (
resultsBreastfeeding was associated with decreased DNA methylation of the glucocorticoid receptor promoter and decreased cortisol reactivity in 5-month-old infants. Decreased DNA methylation occurred in the promoter region involved in regulation of the hypothalamic-pituitary-adrenal and immune system responses.
conclusionsMaternal care in humans may impact the hypothalamic-pituitary-adrenal stress response through behavioral programming and manifest as offspring epigenetic change. These results explain, in part, some of the positive effects observed in children who are breastfed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.