Evidence map›Paper›PMID 30257696›Full record

ArticleTrials2018

Silver diamine fluoride versus therapeutic sealants for the arrest and prevention of dental caries in low-income minority children: study protocol for a cluster randomized controlled trial.

Ryan Richard Ruff, Richard Niederman

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03442309 (Silver Diamine Fluoride Versus Therapeutic Sealants for the Arrest and Prevention of Dental Caries in Low-income Minority Children), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03442309 nacompletednot on this mapstarted 2019, after this paper: background citation

Silver Diamine Fluoride Versus Therapeutic Sealants for the Arrest and Prevention of Dental Caries in Low-income Minority Children

TypeinterventionalSponsorNYU College of DentistryRan2019 to 2023Enrolled7,418ConditionsDental Caries, Quality of LifeArmsSilver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Interventions for treating cavitated or dentine carious lesions.The Cochrane database of systematic reviews · 2021
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  17. Effects of a probiotic drink containingThe Journal of international medical research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ryan Richard RuffDepartment of Epidemiology and Health Promotion, New York University College of Dentistry, 433 First Avenue, Room 712, New York, NY, 10010, USA. ryan.ruff@nyu.edu.ORCID http://orcid.org/0000-0003-0731-5614
Richard NiedermanDepartment of Epidemiology and Health Promotion, New York University College of Dentistry, 433 First Avenue, Room 712, New York, NY, 10010, USA.
York University · US

Funding

Patient-Centered Outcomes Research Institute PCS-1609-36824
6 · The paper itself

Abstract

backgroundDental caries is the most prominent childhood disease in the world. In the United States, more than 50% of children have experienced caries. Untreated caries can have negative impacts on quality of life, academic performance, and school attendance. To reduce oral health disparities, multiple organizations recommend school-based caries prevention. METHODS/

designA longitudinal, cluster randomized, non-inferiority trial will be conducted in low-income children from primarily Hispanic/Latino backgrounds currently enrolled in public elementary schools in New York City, New York, United States, from 2018 to 2023. The primary objective is to compare the non-inferiority of silver diamine fluoride and fluoride varnish versus glass ionomer therapeutic sealants and fluoride varnish in the arrest and prevention of dental caries. Secondary objectives are to evaluate differences in effectiveness when care is provided by nurses versus dental hygienists and assess the impact of prevention on oral health-related quality of life and educational outcomes. Caries arrest will be evaluated after 2 years, and caries prevention and secondary outcomes will be assessed at the completion of the study. Data analysis will follow intent-to-treat, and statistical analyses will be conducted using a two-sided significance level of 0.05. DISCUSSION: The comparative effectiveness of alternative caries prevention delivery models is considered to be one of the highest research priorities in the United States. Many treatments are currently available to prevent and arrest dental caries. The simplicity and affordability of silver diamine fluoride may be a viable alternative for the prevention of dental caries in high-risk children.

trial registrationU.S. National Library of Medicine, www.clinicaltrials.gov , ID: NCT03442309 . Registered on 22 February 2018.

Indexed as

Minority GroupsMinority HealthPovertyAge FactorsChildChild, PreschoolDental Care for ChildrenDental CariesEquivalence Trials as TopicFemaleFluorides, TopicalGlass Ionomer CementsHumansLongitudinal StudiesMaleNew York CityFluorides, TopicalGlass Ionomer CementsPit and Fissure SealantsQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideCaries arrestCaries preventionDental cariesEducationInterim therapeutic restorationsQuality of lifeSealantsSilver diamine fluoride

Identifiers

PMID30257696
PMCPMC6158895
OpenAlexW2893198431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.