Evidence map›Paper›PMID 30257680›Full record

ArticleBMC veterinary research2018

Identification of novel B-cell epitope in gp85 of subgroup J avian leukosis virus and its application in diagnosis of disease.

Kun Qian, Xue Tian, Hongxia Shao, Jianqiang Ye, Yongxiu Yao, Venugopal Nair, Aijian Qin

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Kun QianMinistry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, No.12 East Wenhui Road, Yangzhou, Jiangsu, 225009, People's Republic of China.
Xue TianMinistry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, No.12 East Wenhui Road, Yangzhou, Jiangsu, 225009, People's Republic of China.
Hongxia ShaoMinistry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, No.12 East Wenhui Road, Yangzhou, Jiangsu, 225009, People's Republic of China.
Jianqiang YeMinistry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, No.12 East Wenhui Road, Yangzhou, Jiangsu, 225009, People's Republic of China.
Yongxiu YaoAvian Oncogenic Virus Group, The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK.
Venugopal NairAvian Oncogenic Virus Group, The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK.
Aijian QinMinistry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, No.12 East Wenhui Road, Yangzhou, Jiangsu, 225009, People's Republic of China. aijian@yzu.edu.cn.ORCID http://orcid.org/0000-0001-5779-273X
Northern Jiangsu People's Hospital · CNThe Pirbright Institute · GBYangzhou University · CN

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00001051National key research and development program 2016YFD0500803National Natural Science Foundation of China 31772734NCFC-RCUK-BBSRC 31761133002Special Foundation for State Basic Research Program of China 2013FY113300-
6 · The paper itself

Abstract

backgroundThe gp85 is the main envelope protein of avian leukosis subgroup J (ALV-J) involved in virus neutralization. Here, we mapped the epitope in ALV-J gp85 by ELISA using synthetic peptides and developed epitope based diagnostic methods for ALV-J infection.

resultsThe results revealed that monoclonal antibody (mAb) JE9 recognized

conclusionsA novel B-cell epitope recognized by the mAb JE9 was identified. The developed peptide-ELISA based on this novel B-cell epitope could be useful in laboratory viral diagnosis, routine surveillance in chicken farms, and also in understanding the pathogenesis of ALV-J.

Indexed as

ChickensAnimalsAntibodies, MonoclonalAntibodies, ViralAvian LeukosisAvian Leukosis VirusEpitope MappingEpitopes, B-LymphocytePoultry DiseasesViral Envelope ProteinsAntibodies, MonoclonalAntibodies, ViralEpitopes, B-LymphocyteViral Envelope ProteinsAntibody detectionAvian leukosis virus subgroup JB-cell epitope mappingEpitope-based peptide ELISA

Identifiers

PMID30257680
PMCPMC6158924
OpenAlexW2894389029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.