ReviewVirulence2018
Innate humoral immune defences in mammals and insects: The same, with differences ?
Review in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 236 citations in OpenAlex.
- Systematic review of innate immune responses againstFrontiers in immunology · 2024Pooled it
- Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps.Journal of advanced research · 2026Review
- Exploring a Pathogenomic Approach and the Galleria mellonella Model to Evaluate the Virulence of Arcobacter butzleri.Current microbiology · 2026Article
- ZipV Is Required for Oxidative Stress Resistance and Pathogenicity inJournal of fungi (Basel, Switzerland) · 2026Article
- Gene expression changes of homologs of human trained immunity markers in the silkworm (Bombyx mori) upon exposure to an innate immunity-enhancing agent.The Journal of veterinary medical science · 2026Article
- Autophagy-dependent cell death and immune responses induced by heteroleptic copper(II), manganese(II), and silver(I) complexes containing dicarboxylate and 1,10-phenanthroline ligands: novel insights from in vitro and in vivo models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Summer-form susceptible, winter-form resistant: differential susceptibility ofFrontiers in cellular and infection microbiology · 2026Article
- Streptococcus pneumoniae upregulates Toll2, Toll9, and defensin genes in Bombyx larvae infection model.PloS one · 2026Article
- Carbon source-driven downregulation of the sRNA AmiL enhancesVirulence · 2025Article
- Disruption ofVirulence · 2025Article
- Stress in dipteran insects mass-reared for sterile insect technique applications.Insect science · 2025Review
- Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella.Nature communications · 2025Article
- Long-Chain Hydrocarbons in the Mucous Layer of theACS omega · 2025Article
- The flavouring agent, 2-octenoic acid kills Galleria mellonella larvae by affecting the cellular and humoral elements of insect immunological system.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Review
- Characterization of temporal expression of immune genes in female locust challenged by fungal pathogen,Frontiers in immunology · 2025Article
- Article
- A taste of one's own medicine:Frontiers in immunology · 2025Article
- What Veterinarians Need to Know About the Newly-Emerging Field of Insects-as-Food-and-Feed.Veterinary sciences · 2024Review
- Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insect immune response demonstrates many similarities to the innate immune response of mammals and a wide range of insects is now employed to assess the virulence of pathogens and produce results comparable to those obtained using mammals. Many of the humoral responses in insects and mammals are similar (e.g. insect transglutaminases and human clotting factor XIIIa) however a number show distinct differences. For example in mammals, melanization plays a role in protection from solar radiation and in skin and hair pigmentation. In contrast, insect melanization acts as a defence mechanism in which the proPO system is activated upon pathogen invasion. Human and insect antimicrobial peptides share distinct structural and functional similarities, insects produce the majority of their AMPs from the fat body while mammals rely on production locally at the site of infection by epithelial/mucosal cells. Understanding the structure and function of the insect immune system and the similarities with the innate immune response of mammals will increase the attractiveness of using insects as in vivo models for studying host - pathogen interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.