Evidence map›Paper›PMID 30257371›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2018

Monocyte subpopulations as important biomarkers of resistence and susceptibility during experimental infection with Leishmania (Leishmania) major.

Tassiane Assiria Fontes Martins, Vitor Silva Barbosa, Gregório Guilherme Almeida, Lis Ribeiro Do Valle Antonelli, Wagner Luiz Tafuri, David M Mosser, Ricardo Gonçalves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tassiane Assiria Fontes MartinsDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Vitor Silva BarbosaDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gregório Guilherme AlmeidaDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Lis Ribeiro Do Valle AntonelliLaboratório de Imunopatologia, CPqRR - FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil.
Wagner Luiz TafuriDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
David M MosserDepartment of Cell Biology and Molecular Genetics and Maryland Pathogen Research Institute and Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA.
Ricardo GonçalvesDepartamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: ricardogoncalves2007@gmail.com.
Universidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BRUniversity of Maryland, College Park · US

Funding

Regulatory macrophages and the host inflammatory responseR01GM102589 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI MOSSER, DAVID M · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM102589
6 · The paper itself

Abstract

Visceral Leishmaniasis is a chronic and lethal, parasitic disease. In the later infection stages, it is known that expressive hematological disorders can be observed, including changes in the frequency and phenotype of certain leukocytes. There is a lack of good prognostic indicators to characterize the on-goin clinical status of the patient. In this study, we have analyzed the frequency of monocyte subpopulations in mice infected with Leishmania major (L. major). Our results show a significant correlation between increased blood monocyte frequency and lesion development in both BALB/c and in the C57BL/6 mice infected with L. major. In BALB/c mice we observed a significant correlation between the frequency of GR1

Indexed as

Amphotericin BAnimalsAntiprotozoal AgentsBiomarkersDisease Models, AnimalFemaleLeishmania majorLeishmaniasis, VisceralMiceMice, Inbred BALB CMice, Inbred C57BLMonocytesSeverity of Illness IndexAmphotericin BAntiprotozoal AgentsBiomarkersBiomarkersLeishmaniaMonocyte subpopulationResistanceSusceptibility

Identifiers

PMID30257371
PMCPMC6196714
OpenAlexW2890778775

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.