ArticleCell reports2018
Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Spatial Mapping of Activity Changes across Sensory Areas Following Visual Deprivation in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.Nature communications · 2023Article
- Article
- Metaplasticity framework for cross-modal synaptic plasticity in adults.Frontiers in synaptic neuroscience · 2022Review
- Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.Frontiers in neural circuits · 2021Article
- Layer 4 Gates Plasticity in Visual Cortex Independent of a Canonical Microcircuit.Current biology : CB · 2020Article
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance.eLife · 2020Article
- Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices.Frontiers in neural circuits · 2019Article
- Emerging Roles of Synapse Organizers in the Regulation of Critical Periods.Neural plasticity · 2019Review
- Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity.PloS one · 2019Article
- How Senses Work Together: Cross-Modal Interactions between Primary Sensory Cortices.Neural plasticity · 2018Review
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Plasticity of thalamocortical (TC) synapses is robust during early development and becomes limited in the adult brain. We previously reported that a short duration of deafening strengthens TC synapses in the primary visual cortex (V1) of adult mice. Here, we demonstrate that deafening restores NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of TC synapses onto principal neurons in V1 layer 4 (L4), which is accompanied by an increase in NMDAR function. In contrast, deafening did not recover long-term depression (LTD) at TC synapses. Potentiation of TC synapses by deafening is absent in parvalbumin-positive (PV+) interneurons, resulting in an increase in feedforward excitation to inhibition (E/I) ratio. Furthermore, we found that a brief duration of deafening adult mice recovers rapid ocular dominance plasticity (ODP) mainly by accelerating potentiation of the open-eye responses. Our results suggest that cross-modal sensory deprivation promotes adult cortical plasticity by specifically recovering TC-LTP and increasing the E/I ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.