Evidence map›Paper›PMID 30257203›Full record

ArticleCell reports2018

Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin.

Gen Zhang, Shikui Tu, Tianxiong Yu, Xiao-Ou Zhang, Swapnil S Parhad, Zhiping Weng, William E Theurkauf

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. piRNA direct the chromatin reader to its genomic targets.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Regulatory roles of PIWI-interacting RNAs in cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. TheeLife · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gen ZhangProgram in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Shikui TuProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Tianxiong YuProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Xiao-Ou ZhangProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Swapnil S ParhadProgram in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Zhiping WengProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address: zhiping.weng@umassmed.edu.
William E TheurkaufProgram in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address: william.theurkauf@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

RNA localization and translational controlR01HD049116 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THEURKAUF, WILLIAM EDWARD · 2005 to 2024
$10.8M
Understanding the architecture, regulation, and function of piRNA-producing genesP01HD078253 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WENG, ZHIPING · 2015 to 2019
$6.5M
NICHD NIH HHS P01 HD078253NICHD NIH HHS R01 HD049116
6 · The paper itself

Abstract

In Drosophila, the piRNAs that guide germline transposon silencing are produced from heterochromatic clusters marked by the HP1 homolog Rhino. We show that Rhino promotes cluster transcript association with UAP56 and the THO complex, forming RNA-protein assemblies that are unique to piRNA precursors. UAP56 and THO are ubiquitous RNA-processing factors, and null alleles of uap56 and the THO subunit gene tho2 are lethal. However, uap56

Indexed as

AnimalsBinding SitesChromosomal Proteins, Non-HistoneDEAD-box RNA HelicasesDrosophila melanogasterDrosophila ProteinsHeterochromatinNuclear ProteinsProtein BindingRNA, Small InterferingChromosomal Proteins, Non-HistoneDEAD-box RNA HelicasesDrosophila ProteinsHel25E protein, DrosophilaHeterochromatinNuclear Proteinsrhi protein, DrosophilaRNA, Small InterferingTHOC5 protein, DrosophilaDrosophiliaheterochromatinpiRNAtransposon silencing

Identifiers

PMID30257203
PMCPMC6235161
OpenAlexW2892519010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.