Evidence map›Paper›PMID 30257199›Full record

ArticleCell reports2018

Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8

Natalija Van Braeckel-Budimir, Steven M Varga, Vladimir P Badovinac, John T Harty

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Innate-like Gene Expression of Lung-Resident Memory CD8American journal of respiratory and critical care medicine · 2021
    Trial
  3. Good neighbors make lasting memory.Nature immunology · 2026
    Article
  4. Antigen-experienced airway CD8Science advances · 2026
    Article
  5. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  6. Article
  7. Article
  8. PD-1 is requisite for skin TNature immunology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. PLZF-expressing CD4Cell communication and signaling : CCS · 2025
    Article
  14. Review
  15. Article
  16. Inverted HA-EV immunization elicits stalk-specific influenza immunity and cross-protection in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalija Van Braeckel-BudimirDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.
Steven M VargaDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
Vladimir P BadovinacDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
John T HartyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-harty@uiowa.edu.
University of Iowa · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Regulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7M
Memory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4M
T resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4M
Memory CD8 T cell immunity to Plasmodium liver stage infecR01AI085515 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2010 to 2020
$4.1M
Balancing protection versus immunopathology by RSV-specific memory CD8 T cellsR01AI124093 · NIAID · UNIVERSITY OF IOWA · PI VARGA, STEVEN M · 2017 to 2020
$1.6M
Impairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2M
CD8+ T Cell effector mechanisms against L. monocytogenesR21AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T. · 2002 to 2002
$331k
NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI085515NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI124093NIAID NIH HHS R21 AI042767NIAID NIH HHS R37 AI042767NIAID NIH HHS T32 AI007511NIGMS NIH HHS R01 GM113961
6 · The paper itself

Abstract

Lung-resident primary memory CD8

Indexed as

Immunologic MemoryAnimalsCD8-Positive T-LymphocytesFemaleLungMiceMice, Inbred C57BLOrthomyxoviridae InfectionsCD8(+) T resident memoryheterosubtypic protectioninfluenzalung

Identifiers

PMID30257199
PMCPMC6258017
OpenAlexW2892654499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.