ArticleAmerican journal of respiratory and critical care medicine2019
Intrathoracic Airway Closure Impacts CO
Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07114510 (OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)
Who cites it
32 citing papers in PubMed, 84 citations in OpenAlex.
- PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography.Intensive care medicine experimental · 2026Review
- Intrathoracic effects of PEEP: beyond oxygenation.Intensive care medicine · 2026Article
- Intrathoracic airway closure: a progressively increasing barrier to ventilation during cardiopulmonary resuscitation?Resuscitation plus · 2026Article
- Continuous ventilation versus 30:2 strategy in mechanical cardiopulmonary resuscitation - a manikin-based simulation study.BMC emergency medicine · 2026Article
- Continuous Compressions, Incomplete Ventilation? A Retrospective Analysis of mCPR in Admitted ED Patients.Journal of clinical medicine · 2026Article
- Evaluation of ventilatory parameters reporting in large animal models of cardiac arrest: a scoping review.Resuscitation plus · 2026Article
- Airway opening pressure in mechanically ventilated patients: regional distribution and impact of body position.Critical care (London, England) · 2025Article
- Venovenous extracorporeal membrane oxygenation with mechanical chest compression for cardiopulmonary resuscitation: A porcine model study.JTCVS open · 2025Article
- Erroneous calibration of esophageal pressure in case of airway closure.Critical care (London, England) · 2025Article
- A multimodal characterization of cardiopulmonary resuscitation-associated lung edema.Intensive care medicine experimental · 2024Article
- A new physiological manikin to test and compare ventilation devices during cardiopulmonary resuscitation.Resuscitation plus · 2024Article
- Detecting Intrathoracic Airway Closure during Prehospital Cardiopulmonary Resuscitation Using Quasi-Static Pressure-Volume Curves: A Pilot Study.Journal of clinical medicine · 2024Article
- Integrating rSOResuscitation plus · 2024Article
- A quantitative evaluation of aerosol generation during cardiopulmonary resuscitation.Anaesthesia · 2024Article
- The Role of Chest Compressions on Ventilation during Advanced Cardiopulmonary Resuscitation.Journal of clinical medicine · 2023Article
- Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest.Intensive care medicine experimental · 2023Article
- A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations.Critical care (London, England) · 2022Article
- Reliability of mechanical ventilation during continuous chest compressions: a crossover study of transport ventilators in a human cadaver model of CPR.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model.Intensive care medicine experimental · 2021Article
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Authors and funding
15 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleEnd-tidal CO
objectivesTo understand the impact of airway closure during CPR, and the relationship between the capnogram shape, airway closure, and delivered ventilation.
methodsThis study had three parts: 1) a clinical study analyzing capnograms after intubation in patients with out-of-hospital cardiac arrest receiving continuous chest compressions, 2) a bench model, and 3) experiments with human cadavers. For 2 and 3, a constant CO MEASUREMENTS AND MAIN
resultsA total of 89 patients were analyzed (mean age, 69 ± 15 yr; 23% female; 12% of hospital admission survival): capnograms exhibited various degrees of oscillations, quantified by the opening index. CO
conclusionsDuring chest compressions, intrathoracic airway patency greatly affects the delivered ventilation. The expired CO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.