Observational studyEuropean heart journal. Quality of care & clinical outcomes2019
A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation.
Observational study in European heart journal. Quality of care & clinical outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical Frailty Scale as a predictor of adverse outcomes following aortic valve replacement: a systematic review and meta-analysis.Open heart · 2023Pooled it
- Comparing health outcomes between coronary interventions in frail patients aged 75 years or older with acute coronary syndrome: a systematic review.European geriatric medicine · 2022Pooled it
- Measurement and prognosis of frail patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- FOOPAS Study: Functional Assessment and Prognostic Value in Aortic Valve Replacement for Patients ≥ 75 Years.Journal of clinical medicine · 2026Article
- Relationship between nutrition status and muscle mass and its impact on 1-year mortality in patients with aortic stenosis undergoing transcatheter aortic valve implantation.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications.World journal of cardiology · 2025Review
- Multiparametric Outcome Assessment After Transcatheter Aortic Valve Implantation-A Systematic Review.Journal of clinical medicine · 2025Review
- [Geriatric assessment goes digital-Possible applications in the emergency department setting].Zeitschrift fur Gerontologie und Geriatrie · 2024Review
- Article
- Article
- OLD-TAVR score to predict 2-year mortality in patients aged 75 years and more undergoing transcatheter aortic valve replacement.European geriatric medicine · 2023Article
- Diagnosis and Management of Aortic Valvular Disease in the Elderly.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- Impact of frailty on mortality and quality of life in patients with a history of cancer undergoing transcatheter aortic valve replacement.Clinical cardiology · 2022Article
- Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement.Journal of cardiothoracic surgery · 2022Article
- Low Circulating Musclin is Associated With Adverse Prognosis in Patients Undergoing Transcatheter Aortic Valve Implantation at Low-Intermediate Risk.Journal of the American Heart Association · 2022Article
- Article
- Futility in Transcatheter Aortic Valve Implantation: A Search for Clarity.Interventional cardiology (London, England) · 2022Review
- The Pandora's Box of Frailty Assessments: Which Is the Best for Clinical Purposes in TAVI Patients? A Critical Review.Journal of clinical medicine · 2021Review
- Predictors of clinical outcome following transcatheter aortic valve implantation: a prospective cohort study.Open heart · 2021Observational
- Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest.Journal of clinical medicine · 2021Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEstablished surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients likely to benefit from treatment. The aim of the study was to develop a frailty score to guide the decision for TAVI. METHODS AND
resultsWe conducted a prospective observational study in patients ≥70 years referred for TAVI during 2011-15. A Heart Team had declined the patients for open heart surgery due to high risk but accepted them for TAVI. Prior to the procedure, a geriatric assessment (GA) was performed. Based on this, an 8-element frailty score with a 0-9 (least frail-most frail) scale was developed. A total of 142 patients, 54% women, mean age 83 (standard deviation 4) years, with severe and symptomatic aortic stenosis were assessed. All-cause 2 year mortality was 11%. The novel GA frailty score predicted 2-year mortality in Cox analyses, also when adjusted for age, gender, and logistic EuroSCORE [hazard ratio (HR) 1.75, 95% confidence interval (CI): 1.28-2.42, P < 0.001]. A receiver operating characteristic (ROC) curve analysis indicated that a GA frailty score cut-off at ≥4 predicted 2-year mortality with a specificity of 80% (95% CI: 73-86%) and a sensitivity of 60% (95% CI: 36-80%). The area under the curve was 0.81 (95% CI 0.71-0.90).
conclusionA novel 8-element GA frailty score identified gradations in survival in patients declined for open heart surgery. Patients with higher GA frailty scores had significantly higher 2-year mortality after TAVI.
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