Evidence map›Paper›PMID 30256901›Full record

ArticleBioinformatics (Oxford, England)2019

SemGen: a tool for semantics-based annotation and composition of biosimulation models.

Maxwell L Neal, Christopher T Thompson, Karam G Kim, Ryan C James, Daniel L Cook, Brian E Carlson, John H Gennari

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  9. Publishing reproducible dynamic kinetic models.Briefings in bioinformatics · 2021
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maxwell L NealSeattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, WA, USA.
Christopher T ThompsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Karam G KimDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Ryan C JamesDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Daniel L CookDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Brian E CarlsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
John H GennariDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.

Funding

University of Washington Biomedical Informatics and Data Science Research Training ProgramT15LM007442 · NLM · UNIVERSITY OF WASHINGTON · PI JOHN H. GENNARI, Andrea L. Hartzler · 2002 to 2026
$19.6M
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
Physiological Knowledge Integration and Recombinant Modeling Via Accelerated SemaR01LM011969 · NLM · UNIVERSITY OF WASHINGTON · PI CARLSON, BRIAN E., GENNARI, JOHN H. · 2014 to 2017
$1.7M
NIGMS NIH HHS P41 GM109824NLM NIH HHS R01 LM011969NLM NIH HHS T15 LM007442
6 · The paper itself

Abstract

summaryAs the number and complexity of biosimulation models grows, so do demands for tools that can help users understand models and compose more comprehensive and accurate systems from existing models. SemGen is a tool for semantics-based annotation and composition of biosimulation models designed to address this demand. A key SemGen capability is to decompose and then integrate models across existing model exchange formats including SBML and CellML. To support this capability, we use semantic annotations to explicitly capture the underlying biological and physical meanings of the entities and processes that are modeled. SemGen leverages annotations to expose a model's biological and computational architecture and to help automate model composition. AVAILABILITY AND IMPLEMENTATION: SemGen is freely available at https://github.com/SemBioProcess/SemGen. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

SemanticsSoftware

Identifiers

PMID30256901
PMCPMC6499248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.