ArticleMolecular and cellular biology1986
Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Transcriptomic Analysis of CAD Cell Differentiation.microPublication biology · 2025Article
- TUBB3 and KIF21A in neurodevelopment and disease.Frontiers in neuroscience · 2023Review
- An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.Human molecular genetics · 2012Article
- βV-tubulin expression is associated with outcome following taxane-based chemotherapy in non-small cell lung cancer.British journal of cancer · 2012Article
- Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissue.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Class V β-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.Molecular biology of the cell · 2011Article
- Developmental corneal innervation: interactions between nerves and specialized apical corneal epithelial cells.Investigative ophthalmology & visual science · 2010Article
- Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.The Journal of biological chemistry · 2009Article
- A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation.Molecular biology of the cell · 2004Article
- Extrasynaptic alpha 7-nicotinic acetylcholine receptor expression in developing neurons is regulated by inputs, targets, and activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Innervation and target tissue interactions induce Rab-GDP dissociation inhibitor (GDI) expression during peripheral synapse formation in developing chick ciliary ganglion neurons in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Changes in the regulatory effects of cell-cell interactions on neuronal AChR subunit transcript levels after synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Innervation of the chicken parathyroid glands: immunohistochemical study with the TuJ1, galanin, VIP, substance P, CGRP and tyrosine hydroxylase antibodies.Anatomy and embryology · 1995Article
- Accessory carotid body within the parathyroid gland III of the chicken.Histochemistry and cell biology · 1995Article
- Differential utilization of beta-tubulin isotypes in differentiating neurites.The Journal of cell biology · 1989Article
- Evidence that introns arose at proto-splice sites.The EMBO journal · 1989Article
- Truncation of the carboxy-terminal domain of yeast beta-tubulin causes temperature-sensitive growth and hypersensitivity to antimitotic drugs.The Journal of cell biology · 1988Article
- A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.The EMBO journal · 1988Article
- In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function.The Journal of cell biology · 1987Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the nucleotide sequence of the chicken beta 5 (c beta 5)-tubulin gene. The gene displayed the coding structure common to all previously studied vertebrate beta-tubulin genes and was divided into four exon sequences interrupted by three intervening sequences (located between codons 19 and 20, within codon 56, and within codon 93). Comparison of the predicted polypeptide sequence encoded by c beta 5 with those of four other available chicken beta-tubulin sequences revealed that c beta 5 encoded a highly divergent beta-tubulin polypeptide isotype which was distinguished from previously known sequences primarily by two discrete variable sequence domains. However, c beta 5 uniquely shared identity in 16 residue positions with another divergent chicken beta-tubulin gene, c beta 4. These common sequences distinguished c beta 4 and c beta 5 from the remaining three chicken beta-tubulin genes. Analysis of the expression of c beta 5 and c beta 4 revealed a strikingly complementary pattern of gene expression: c beta 5 was expressed in a wide variety of cell and tissue types but not in neurons, whereas c beta 4 expression was detected uniquely in neuronal cells. Overall, these findings suggest the existence of two divergent families of beta-tubulin sequences in the chicken and further raise the possibility that the complementary expression of the c beta 4 and c beta 5 genes may fulfill a requirement for the presence of a divergent beta-tubulin polypeptide isotype in all cell types.
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