ArticlePediatric obesity2019
Childhood obesity, weight loss and developmental trajectories predict the persistence and remission of childhood sleep-disordered breathing.
Article in Pediatric obesity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Short-Term Weight Gain after Tonsillectomy Does Not Lead to Overweight: A Systematic Review.Nutrients · 2024Pooled it
- MicroRNAs as the promising markers of comorbidities in childhood obesity-A systematic review.Pediatric obesity · 2022Pooled it
- Article
- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Associations between body mass index, sleep-disordered breathing, brain structure, and behavior in healthy children.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Disparities in Sleep-Disordered Breathing: Upstream Risk Factors, Mechanisms, and Implications.Clinics in chest medicine · 2023Review
- Association of Pediatric Obstructive Sleep Apnea With Elevated Blood Pressure and Orthostatic Hypertension in Adolescence.JAMA cardiology · 2021Article
- Article
- Association of visceral adiposity and systemic inflammation with sleep disordered breathing in normal weight, never obese adolescents.Sleep medicine · 2020Article
- Correlations between obstructive sleep apnea and adenotonsillar hypertrophy in children of different weight status.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundObesity has been recognized as a risk factor for childhood sleep-disordered breathing (SDB), yet it remains unclear how obesity and weight change predict the course of childhood SDB.
objectiveThe objective of the study is to investigate the role of body weight, upper airway abnormalities and developmental trajectories on the persistence and remission of childhood SDB in the transition to adolescence.
methodsThe Penn State Child Cohort is a representative population sample of 700 children (5-12 years), of whom 421 were followed up as adolescents (12-23 years). Participants underwent a clinical history, physical examination and polysomnography at both time points.
resultsObesity and enlarged tonsils were cross-sectionally associated with childhood SDB. Longitudinally, baseline obesity predicted the persistence of childhood SDB (OR = 3.75, 95% CI = 2.00-7.05), while weight loss predicted its remission (OR = 1.67, 95% CI = 1.11-2.50). Children with enlarged tonsils who remitted from SDB had not experienced significant weight loss and only 4.4% had undergone adeno/tonsillectomy. Body fat distribution/composition at follow-up was similar in those who had remitted from childhood SDB as compared with those who had never experienced SDB, while those who persisted with childhood SDB showed significant android distribution and visceral adiposity at follow-up.
conclusionsOur data support a causal role for obesity and weight loss in the chronicity and remission, respectively, of childhood SDB in the transition to adolescence and suggest that remission of SDB is related to developmental trajectories of the upper airway in a significant proportion of children. Thus, targeting childhood obesity and weight gain should be a priority in the prevention and treatment of SDB during this critical developmental period.
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