Evidence map›Paper›PMID 30256533›Full record

ArticleMacromolecular bioscience2018

Reactive Ion Plasma Modification of Poly(Vinyl-Alcohol) Increases Primary Endothelial Cell Affinity and Reduces Thrombogenicity.

Patrick L Jurney, Deirdre E J Anderson, Grace Pohan, Evelyn K F Yim, Monica T Hinds

Open access · greenAbstract read
In one paragraph

Article in Macromolecular bioscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Patrick L JurneyDr. P. L. Jurney, Dr. D. E. J. Anderson, Prof. M. T. Hinds, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.ORCID 0000-0002-4099-2927
Deirdre E J AndersonDr. P. L. Jurney, Dr. D. E. J. Anderson, Prof. M. T. Hinds, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.
Grace PohanG. Pohan, Prof. E. K. F. Yim, Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1.
Evelyn K F YimG. Pohan, Prof. E. K. F. Yim, Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1.
Monica T HindsDr. P. L. Jurney, Dr. D. E. J. Anderson, Prof. M. T. Hinds, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA.
Oregon Health & Science University · USUniversity of Waterloo · CA

Funding

Contact Pathway Activation on Vascular DevicesR01HL144113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HINDS, MONICA T, MCCARTY, OWEN J · 2018 to 2025
$6.0M
Surface Modification Compliant Vascular GraftsR01HL130274 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HINDS, MONICA T, YIM, EVELYN KING FAI · 2016 to 2019
$2.6M
Microengineering the Dental Pulp Vascular Microenvironment_Diversity SupplementR01DE026170 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI BERTASSONI, LUIZ EDUARDO · 2016 to 2020
$2.5M
NHLBI NIH HHS R01 HL130274NHLBI NIH HHS R01 HL144113NIDCR NIH HHS R01 DE026170
6 · The paper itself

Abstract

Bulk material properties and luminal surface interaction with blood determine the clinical viability of vascular grafts, and reducing intimal hyperplasia is necessary to improve their long-term patency. Here, the authors report that the surface of a biocompatible hydrogel material, poly(vinyl alcohol) (PVA) can be altered by exposing it to reactive ion plasma (RIP) in order to increase primary endothelial cell attachment. The power and the carrier gas of the RIP treatment are varied and the resultant surface nitrogen, water contact angle, as well as the ability of the RIP-treated surfaces to support primary endothelial colony forming cells is characterized. Additionally, in a clinically relevant shunt model, the amounts of platelet and fibrin attachment to the surface were quantified during exposure to non-anticoagulated blood. Treatments with all carrier gases resulted in an increase in the surface nitrogen. Treating PVA with O

Indexed as

Platelet AdhesivenessPolyvinyl AlcoholThrombosisAnimalsBlood PlateletsCells, CulturedEndothelial CellsPapio anubisPlasma GasesPlasma GasesPolyvinyl Alcoholendothelial colony forming cellsreactive ion plasmasynthetic biomaterialsthrombogenicityvascular grafts

Identifiers

PMID30256533
PMCPMC6644031
OpenAlexW2890067735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.