ArticleAngewandte Chemie (International ed. in English)2019
Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Regio- and Enantioselective Alkoxycarbonylation of Unactivated Terminal Alkenes under Palladium-Bromide-Monophosphine Catalysis.Journal of the American Chemical Society · 2026Article
- Catalytic Asymmetric Hydration of Alkenes.Journal of the American Chemical Society · 2026Article
- Electrochemical hydroxylation of alkenes with HNational science review · 2026Article
- Unlocking the Versatility of Linalool Dehydratase Reactivity: Tunable Stereochemical Control in Olefin Formation via Organic Synthesis.ACS catalysis · 2025Article
- A Thermostable Fatty Acid Hydratase from Marinitoga Piezophila with Low Temperature Optimum and Broad Product Scope.Chembiochem : a European journal of chemical biology · 2025Article
- Regioselective Hydration of Terpenes with Cofactor-Independent Carotenoid 1,2-Hydratase.Angewandte Chemie (International ed. in English) · 2025Article
- Review
- Biocatalytic, Stereoconvergent Alkylation of (Nature synthesis · 2024Article
- An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin.The Plant cell · 2023Article
- Chiral Alcohols from Alkenes and Water: Directed Evolution of a Styrene Hydratase.Angewandte Chemie (International ed. in English) · 2023Article
- Article
- Towards an understanding of oleate hydratases and their application in industrial processes.Microbial cell factories · 2022Review
- Catalytic Asymmetric Hydroalkoxylation of C-C Multiple Bonds.Chemical reviews · 2021Review
- Fatty Acids and their Derivatives as Renewable Platform Molecules for the Chemical Industry.Angewandte Chemie (International ed. in English) · 2021Review
- Enzymatic strategies for asymmetric synthesis.RSC chemical biology · 2021Review
- Novel oleate hydratases and potential biotechnological applications.Applied microbiology and biotechnology · 2021Review
- Biocatalysis: Enzymatic Synthesis for Industrial Applications.Angewandte Chemie (International ed. in English) · 2021Review
- Bioinformatic analysis of subfamily-specific regions in 3D-structures of homologs to study functional diversity and conformational plasticity in protein superfamilies.Computational and structural biotechnology journal · 2021Article
- Zebra2: advanced and easy-to-use web-server for bioinformatic analysis of subfamily-specific and conserved positions in diverse protein superfamilies.Nucleic acids research · 2020Article
- Unexpected NADPH Hydratase Activity in the Nitrile Reductase QueF from Escherichia coli.Chembiochem : a European journal of chemical biology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long-standing challenge in catalysis. Here we report that an engineered fatty acid hydratase can catalyze the asymmetric hydration of various terminal and internal alkenes. In the presence of a carboxylic acid decoy molecule for activation of the oleate hydratase from E. meningoseptica, asymmetric hydration of unactivated alkenes was achieved with up to 93 % conversion, excellent selectivity (>99 % ee, >95 % regioselectivity), and on a preparative scale.
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