Evidence map›Paper›PMID 30256496›Full record

ArticleHuman brain mapping2019

A MATLAB toolbox for multivariate analysis of brain networks.

Mohsen Bahrami, Paul J Laurienti, Sean L Simpson

Abstract read
In one paragraph

Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. A mixed-modeling framework for whole-brain dynamic network analysis.Network neuroscience (Cambridge, Mass.) · 2022
    Article
  11. Article
  12. Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohsen BahramiLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Paul J LaurientiLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Sean L SimpsonLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D. · 2016 to 2020
$12.2M
The Effect of Pesticide Exposure on Cognitive and Brain Development in Latino Children: PACE5 Administrative Supplement 2R01ES008739 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARCURY, THOMAS A., LAURIENTI, PAUL · 2000 to 2022
$11.1M
Analytical Tools for Complex Brain Networks: Fusing Novel Statistical Methods and Network Science to Understand Brain FunctionR01EB024559 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2018 to 2021
$1.5M
Statistical Methods for Whole-Brain Connectivety NetworksK25EB012236 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2012 to 2016
$796k
REDUCING FARMWORKERS EXPOSURE TO AGRICULTURAL CHEMICALSR21ES008739 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARCURY, THOMAS A · 1996 to 1999
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NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG049638NIBIB NIH HHS ES008739NIBIB NIH HHS K25 EB012236NIBIB NIH HHS R01NIBIB NIH HHS R01 EB024559NIEHS NIH HHS R01 ES008739NIEHS NIH HHS R21 ES008739
6 · The paper itself

Abstract

Complex brain networks formed via structural and functional interactions among brain regions are believed to underlie information processing and cognitive function. A growing number of studies indicate that altered brain network topology is associated with physiological, behavioral, and cognitive abnormalities. Graph theory is showing promise as a method for evaluating and explaining brain networks. However, multivariate frameworks that provide statistical inferences about how such networks relate to covariates of interest, such as disease phenotypes, in different study populations are yet to be developed. We have developed a freely available MATLAB toolbox with a graphical user interface that bridges this important gap between brain network analyses and statistical inference. The modeling framework implemented in this toolbox utilizes a mixed-effects multivariate regression framework that allows assessing brain network differences between study populations as well as assessing the effects of covariates of interest such as age, disease phenotype, and risk factors on the density and strength of brain connections in global (i.e., whole-brain) and local (i.e., subnetworks) brain networks. Confounding variables, such as sex, are controlled for through the implemented framework. A variety of neuroimaging data such as fMRI, EEG, and DTI can be analyzed with this toolbox, which makes it useful for a wide range of studies examining the structure and function of brain networks. The toolbox uses SAS, R, or Python (depending on software availability) to perform the statistical modeling. We also provide a clustering-based data reduction method that helps with model convergence and substantially reduces modeling time for large data sets.

Indexed as

Data Interpretation, StatisticalModels, TheoreticalSoftwareBrainHumansImage Processing, Computer-AssistedMultivariate AnalysisNerve NetNeuroimagingbrain connectionsbrain networksMATLAB toolboxmixed-effects regressionmultivariate modeling

Identifiers

PMID30256496
PMCPMC6289822

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.