ArticleThe New phytologist2019
DNA methylation dynamics during the interaction of wheat progenitor Aegilops tauschii with the obligate biotrophic fungus Blumeria graminis f. sp. tritici.
Article in The New phytologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
- The landscape of cotton DNA methylation and its epigenetic regulation in Verticillium wilt resistance.Plant cell reports · 2026Article
- Genomics in wheat improvement: Progress and perspectives.The plant genome · 2026Review
- A Genome-Wide DNA Methylation Survey Reveals Salicylic Acid-Induced Distinct Hypomethylation Linked to Defense Responses Against Biotrophic Pathogens.International journal of molecular sciences · 2026Article
- Genome-wide DNA methylation landscape and its association with the transcriptome reprogramming in potato in response toHorticulture research · 2026Article
- How to improve crop pathogen resistance with epigenetics.Phytopathology research · 2026Review
- Plant Defense Responses to Insect Herbivores Through Molecular Signaling, Secondary Metabolites, and Associated Epigenetic Regulation.Plant-environment interactions (Hoboken, N.J.) · 2025Review
- An3 Biotech · 2025Article
- Article
- Broad-scale phenotyping in Arabidopsis reveals varied involvement of RNA interference across diverse plant-microbe interactions.Plant direct · 2024Article
- DNA methylation analysis reveals local changes in resistant and susceptible soybean lines in response to Phytophthora sansomeana.G3 (Bethesda, Md.) · 2024Article
- A high-quality haplotype genome of Michelia alba DC reveals differences in methylation patterns and flower characteristics.Molecular horticulture · 2024Article
- Epigenetic weapons of plants against fungal pathogens.BMC plant biology · 2024Review
- Screening and Analysis of Antifungal StrainsJournal of fungi (Basel, Switzerland) · 2023Article
- Epigenetic regulation of plant immunity: from chromatin codes to plant disease resistance.aBIOTECH · 2023Review
- DDM1-mediated gene body DNA methylation is associated with inducible activation of defense-related genes in Arabidopsis.Genome biology · 2023Article
- Endophytic fungi: hidden treasure chest of antimicrobial metabolites interrelationship of endophytes and metabolites.Frontiers in microbiology · 2023Review
- Triticeae crop genome biology: an endless frontier.Frontiers in plant science · 2023Review
- Methylome changes inFrontiers in plant science · 2023Article
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- DNA methylation dynamics in response to abiotic and pathogen stress in plants.Plant cell reports · 2022Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
DNA methylation is dynamically involved in plant immunity, but little information is known about its roles in plant interactions with biotrophic fungi, especially in temperate grasses such as wheat (Triticum aestivum). Using wheat diploid progenitor Aegilops tauschii accession AL8/78, the genome of which has been sequenced, we assessed the extent of DNA methylation in response to infection with Blumeria graminis f. sp. tritici (Bgt), which causes powdery mildew. Upon Bgt infection, ARGONAUTE4a (AGO4a) was significantly downregulated in A. tauschii, which was accompanied by a substantial reduction in AGO4a-sorted 24-nt siRNA levels, especially for genes near transposable elements (TAGs). Bisulfite sequencing revealed abundant differentially methylated regions (DMRs) with CHH hypomethylation. TAGs bearing CHH-hypomethylated DMRs were enriched for 'response to stress' functions, including receptor kinase, peroxidase, and pathogenesis-related genes. Virus-induced gene silencing (VIGS) of a DOMAINS REARRANGED METHYLASE 2 (DRM2) homolog enhanced plant resistance to Bgt. The effect of CHH hypomethylation was exemplified by the upregulation of a pathogenesis-related β-1,3-glucanse gene implicated in Bgt defense. These findings support the idea that dynamic DNA methylation represents a regulatory layer in the complex mechanism of plant immunity, which could be exploited to improve disease resistance in common wheat.
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