Evidence map›Paper›PMID 30256418›Full record

ArticleJournal of medical primatology2018

Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes.

Daniel R Ram, Kyle Kroll, R Keith Reeves

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel R RamHarvard Medical School, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-9841-9525
Kyle KrollHarvard Medical School, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-9237-9497
R Keith ReevesHarvard Medical School, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0003-3157-2557
Beth Israel Deaconess Medical Center · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Microbial and innate immune mechanisms of oral inflammation during SIV infectionR01DE026327 · NIDCR · DUKE UNIVERSITY · PI REEVES, ROGER KEITH · 2016 to 2020
$3.9M
Mechanisms of innate modulation of SIV reservoirs and opportunistic disease in the oral cavityR01DE026014 · NIDCR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI REEVES, ROGER KEITH · 2016 to 2020
$3.4M
NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007387NIDCR NIH HHS R01 DE026014NIDCR NIH HHS R01 DE026327
6 · The paper itself

Abstract

The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional NK cell responses to pathogen-associated molecular patterns (PAMPs) of potential oral pathogens in rhesus macaques.

Indexed as

Immunity, InnateMacaca mulattaAnimalsKiller Cells, NaturalLymph NodesPathogen-Associated Molecular Pattern MoleculesSimian Acquired Immunodeficiency SyndromePathogen-Associated Molecular Pattern Molecules

Identifiers

PMID30256418
PMCPMC6161495
OpenAlexW2892059555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.